node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bub1 | Bub1b | ENSRNOP00000042114 | ENSRNOP00000010406 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | BUB1 mitotic checkpoint serine/threonine kinase B. | 0.996 |
Bub1 | Bub3 | ENSRNOP00000042114 | ENSRNOP00000028020 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | BUB3 mitotic checkpoint protein. | 0.995 |
Bub1 | Cdc20 | ENSRNOP00000042114 | ENSRNOP00000037772 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] | 0.999 |
Bub1 | Cdk1 | ENSRNOP00000042114 | ENSRNOP00000070138 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.980 |
Bub1 | Mad1l1 | ENSRNOP00000042114 | ENSRNOP00000001709 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Mitotic arrest deficient 1-like 1. | 0.991 |
Bub1 | Mad2l1 | ENSRNOP00000042114 | ENSRNOP00000007285 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | MAD2 (Mitotic arrest deficient, homolog)-like 1 (Yeast) (Predicted), isoform CRA_a. | 0.998 |
Bub1 | Melk | ENSRNOP00000042114 | ENSRNOP00000059313 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Maternal embryonic leucine zipper kinase (Predicted); Belongs to the protein kinase superfamily. | 0.980 |
Bub1 | Ndc80 | ENSRNOP00000042114 | ENSRNOP00000072111 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | NDC80 kinetochore complex component. | 0.987 |
Bub1 | Plk1 | ENSRNOP00000042114 | ENSRNOP00000025629 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | 0.980 |
Bub1 | Ttk | ENSRNOP00000042114 | ENSRNOP00000072355 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Ttk protein kinase. | 0.988 |
Bub1b | Bub1 | ENSRNOP00000010406 | ENSRNOP00000042114 | BUB1 mitotic checkpoint serine/threonine kinase B. | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | 0.996 |
Bub1b | Bub3 | ENSRNOP00000010406 | ENSRNOP00000028020 | BUB1 mitotic checkpoint serine/threonine kinase B. | BUB3 mitotic checkpoint protein. | 0.998 |
Bub1b | Cdc20 | ENSRNOP00000010406 | ENSRNOP00000037772 | BUB1 mitotic checkpoint serine/threonine kinase B. | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] | 0.999 |
Bub1b | Cdk1 | ENSRNOP00000010406 | ENSRNOP00000070138 | BUB1 mitotic checkpoint serine/threonine kinase B. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.982 |
Bub1b | Mad1l1 | ENSRNOP00000010406 | ENSRNOP00000001709 | BUB1 mitotic checkpoint serine/threonine kinase B. | Mitotic arrest deficient 1-like 1. | 0.991 |
Bub1b | Mad2l1 | ENSRNOP00000010406 | ENSRNOP00000007285 | BUB1 mitotic checkpoint serine/threonine kinase B. | MAD2 (Mitotic arrest deficient, homolog)-like 1 (Yeast) (Predicted), isoform CRA_a. | 0.999 |
Bub1b | Melk | ENSRNOP00000010406 | ENSRNOP00000059313 | BUB1 mitotic checkpoint serine/threonine kinase B. | Maternal embryonic leucine zipper kinase (Predicted); Belongs to the protein kinase superfamily. | 0.901 |
Bub1b | Ndc80 | ENSRNOP00000010406 | ENSRNOP00000072111 | BUB1 mitotic checkpoint serine/threonine kinase B. | NDC80 kinetochore complex component. | 0.991 |
Bub1b | Plk1 | ENSRNOP00000010406 | ENSRNOP00000025629 | BUB1 mitotic checkpoint serine/threonine kinase B. | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | 0.995 |
Bub1b | Ttk | ENSRNOP00000010406 | ENSRNOP00000072355 | BUB1 mitotic checkpoint serine/threonine kinase B. | Ttk protein kinase. | 0.969 |