node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdc45 | Clspn | ENSRNOP00000066206 | ENSRNOP00000015227 | Similar to cell division cycle 45 homolog (S. cerevisiae)-like. | Claspin homolog (Xenopus laevis) (Predicted). | 0.982 |
Cdc45 | Mcm2 | ENSRNOP00000066206 | ENSRNOP00000022231 | Similar to cell division cycle 45 homolog (S. cerevisiae)-like. | DNA helicase; Belongs to the MCM family. | 0.999 |
Cdc45 | Mcm5 | ENSRNOP00000066206 | ENSRNOP00000070472 | Similar to cell division cycle 45 homolog (S. cerevisiae)-like. | DNA helicase; Belongs to the MCM family. | 0.999 |
Cdc45 | Mcm7 | ENSRNOP00000066206 | ENSRNOP00000001825 | Similar to cell division cycle 45 homolog (S. cerevisiae)-like. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
Cdc45 | Timeless | ENSRNOP00000066206 | ENSRNOP00000070516 | Similar to cell division cycle 45 homolog (S. cerevisiae)-like. | Protein timeless homolog; Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (By similarity). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (B [...] | 0.983 |
Cdc45 | Tipin | ENSRNOP00000066206 | ENSRNOP00000059833 | Similar to cell division cycle 45 homolog (S. cerevisiae)-like. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.948 |
Cdc45 | Tipinl1 | ENSRNOP00000066206 | ENSRNOP00000053083 | Similar to cell division cycle 45 homolog (S. cerevisiae)-like. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. | 0.947 |
Cdc45 | Wdhd1 | ENSRNOP00000066206 | ENSRNOP00000015100 | Similar to cell division cycle 45 homolog (S. cerevisiae)-like. | WD repeat and HMG-box DNA binding protein 1 (Predicted). | 0.991 |
Clspn | Cdc45 | ENSRNOP00000015227 | ENSRNOP00000066206 | Claspin homolog (Xenopus laevis) (Predicted). | Similar to cell division cycle 45 homolog (S. cerevisiae)-like. | 0.982 |
Clspn | Mcm2 | ENSRNOP00000015227 | ENSRNOP00000022231 | Claspin homolog (Xenopus laevis) (Predicted). | DNA helicase; Belongs to the MCM family. | 0.936 |
Clspn | Mcm5 | ENSRNOP00000015227 | ENSRNOP00000070472 | Claspin homolog (Xenopus laevis) (Predicted). | DNA helicase; Belongs to the MCM family. | 0.896 |
Clspn | Mcm7 | ENSRNOP00000015227 | ENSRNOP00000001825 | Claspin homolog (Xenopus laevis) (Predicted). | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.845 |
Clspn | Timeless | ENSRNOP00000015227 | ENSRNOP00000070516 | Claspin homolog (Xenopus laevis) (Predicted). | Protein timeless homolog; Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (By similarity). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (B [...] | 0.994 |
Clspn | Tipin | ENSRNOP00000015227 | ENSRNOP00000059833 | Claspin homolog (Xenopus laevis) (Predicted). | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.985 |
Clspn | Tipinl1 | ENSRNOP00000015227 | ENSRNOP00000053083 | Claspin homolog (Xenopus laevis) (Predicted). | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. | 0.985 |
Clspn | Wdhd1 | ENSRNOP00000015227 | ENSRNOP00000015100 | Claspin homolog (Xenopus laevis) (Predicted). | WD repeat and HMG-box DNA binding protein 1 (Predicted). | 0.919 |
Cry1 | Cry2 | ENSRNOP00000009124 | ENSRNOP00000010142 | Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] | Cryptochrome-2; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] | 0.998 |
Cry1 | Timeless | ENSRNOP00000009124 | ENSRNOP00000070516 | Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] | Protein timeless homolog; Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (By similarity). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (B [...] | 0.982 |
Cry2 | Cry1 | ENSRNOP00000010142 | ENSRNOP00000009124 | Cryptochrome-2; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] | Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] | 0.998 |
Cry2 | Timeless | ENSRNOP00000010142 | ENSRNOP00000070516 | Cryptochrome-2; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] | Protein timeless homolog; Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (By similarity). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (B [...] | 0.982 |