node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Epn1 | Usp9x | ENSRNOP00000021286 | ENSRNOP00000072190 | Epsin-1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis; Belongs to the epsin family. | Ubiquitin-specific peptidase 9, X-linked; Belongs to the peptidase C19 family. | 0.767 |
Epn1 | Zup1 | ENSRNOP00000021286 | ENSRNOP00000000448 | Epsin-1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis; Belongs to the epsin family. | Zinc finger-containing ubiquitin peptidase 1; Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress. Belongs to the peptidase C78 family. ZUFSP subfamily. | 0.622 |
Idh3g | Usp9x | ENSRNOP00000073128 | ENSRNOP00000072190 | Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. | Ubiquitin-specific peptidase 9, X-linked; Belongs to the peptidase C19 family. | 0.698 |
LOC103690024 | Pex26 | ENSRNOP00000070292 | ENSRNOP00000065481 | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | Similar to peroxisome biogenesis factor 26. | 0.901 |
LOC103690024 | Usp9x | ENSRNOP00000070292 | ENSRNOP00000072190 | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | Ubiquitin-specific peptidase 9, X-linked; Belongs to the peptidase C19 family. | 0.700 |
Nuak1 | Usp9x | ENSRNOP00000010636 | ENSRNOP00000072190 | NUAK family, SNF1-like kinase, 1. | Ubiquitin-specific peptidase 9, X-linked; Belongs to the peptidase C19 family. | 0.835 |
Pex26 | LOC103690024 | ENSRNOP00000065481 | ENSRNOP00000070292 | Similar to peroxisome biogenesis factor 26. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.901 |
Pex26 | Usp9x | ENSRNOP00000065481 | ENSRNOP00000072190 | Similar to peroxisome biogenesis factor 26. | Ubiquitin-specific peptidase 9, X-linked; Belongs to the peptidase C19 family. | 0.720 |
Smad4 | Usp9x | ENSRNOP00000074882 | ENSRNOP00000072190 | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] | Ubiquitin-specific peptidase 9, X-linked; Belongs to the peptidase C19 family. | 0.938 |
Uchl5 | Usp14 | ENSRNOP00000072164 | ENSRNOP00000020537 | Ubiquitin carboxyl-terminal hydrolase. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.926 |
Uchl5 | Usp5 | ENSRNOP00000072164 | ENSRNOP00000020785 | Ubiquitin carboxyl-terminal hydrolase. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.711 |
Uchl5 | Usp9x | ENSRNOP00000072164 | ENSRNOP00000072190 | Ubiquitin carboxyl-terminal hydrolase. | Ubiquitin-specific peptidase 9, X-linked; Belongs to the peptidase C19 family. | 0.694 |
Uchl5 | Zup1 | ENSRNOP00000072164 | ENSRNOP00000000448 | Ubiquitin carboxyl-terminal hydrolase. | Zinc finger-containing ubiquitin peptidase 1; Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress. Belongs to the peptidase C78 family. ZUFSP subfamily. | 0.669 |
Usp14 | Uchl5 | ENSRNOP00000020537 | ENSRNOP00000072164 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | Ubiquitin carboxyl-terminal hydrolase. | 0.926 |
Usp14 | Usp5 | ENSRNOP00000020537 | ENSRNOP00000020785 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.836 |
Usp14 | Usp9x | ENSRNOP00000020537 | ENSRNOP00000072190 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | Ubiquitin-specific peptidase 9, X-linked; Belongs to the peptidase C19 family. | 0.696 |
Usp14 | Zup1 | ENSRNOP00000020537 | ENSRNOP00000000448 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | Zinc finger-containing ubiquitin peptidase 1; Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress. Belongs to the peptidase C78 family. ZUFSP subfamily. | 0.860 |
Usp5 | Uchl5 | ENSRNOP00000020785 | ENSRNOP00000072164 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | Ubiquitin carboxyl-terminal hydrolase. | 0.711 |
Usp5 | Usp14 | ENSRNOP00000020785 | ENSRNOP00000020537 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.836 |
Usp5 | Usp9x | ENSRNOP00000020785 | ENSRNOP00000072190 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | Ubiquitin-specific peptidase 9, X-linked; Belongs to the peptidase C19 family. | 0.696 |