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Rffl protein (Rattus norvegicus) - STRING interaction network
"Rffl" - E3 ubiquitin-protein ligase rififylin in Rattus norvegicus
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second shell of interactors
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filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RfflE3 ubiquitin-protein ligase rififylin ; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates ’Lys-48’-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signa [...] (362 aa)    
Predicted Functional Partners:
Tp53
Cellular tumor antigen p53 ; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] (391 aa)
     
  0.912
ENSRNOG00000046657
Cellular tumor antigen p53 ; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (261 aa)
     
    0.907
Usp37
Ubiquitin carboxyl-terminal hydrolase (979 aa)
     
   
  0.578
Ripk1
Receptor-interacting serine/threonine-protein kinase 1 (658 aa)
       
    0.544
Josd2
Josephin-2 (188 aa)
           
  0.483
Spryd4
SPRY domain-containing protein 4 (207 aa)
           
  0.481
Nipal4
Magnesium transporter NIPA4 (406 aa)
           
  0.480
Uxt
Protein UXT ; Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association w [...] (157 aa)
           
  0.479
Glcci1
Glucocorticoid induced transcript 1 (430 aa)
     
   
  0.444
Birc6
Baculoviral IAP repeat-containing protein 6 (4029 aa)
     
   
  0.425
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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