node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arrdc4 | Arrdc5 | ENSRNOP00000073183 | ENSRNOP00000064476 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | Arrestin domain-containing 5. | 0.621 |
Arrdc4 | Isoc1 | ENSRNOP00000073183 | ENSRNOP00000026706 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | Isochorismatase domain-containing protein 1; Belongs to the isochorismatase family. | 0.516 |
Arrdc4 | Mlxip | ENSRNOP00000073183 | ENSRNOP00000001690 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | MLX-interacting protein. | 0.574 |
Arrdc4 | Nedd4 | ENSRNOP00000073183 | ENSRNOP00000074683 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/K [...] | 0.707 |
Arrdc4 | Nedd4l | ENSRNOP00000073183 | ENSRNOP00000070352 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | NEDD4-like E3 ubiquitin protein ligase. | 0.612 |
Arrdc4 | Samd12 | ENSRNOP00000073183 | ENSRNOP00000068526 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | Sterile alpha motif domain-containing 12. | 0.535 |
Arrdc4 | Tmem132b | ENSRNOP00000073183 | ENSRNOP00000072599 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | Transmembrane protein 132B. | 0.542 |
Arrdc4 | Trim65 | ENSRNOP00000073183 | ENSRNOP00000047932 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | Tripartite motif-containing 65. | 0.543 |
Arrdc4 | Ubald2 | ENSRNOP00000073183 | ENSRNOP00000013359 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | UBA-like domain-containing 2. | 0.535 |
Arrdc4 | Wwp2 | ENSRNOP00000073183 | ENSRNOP00000018837 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | WW domain-containing E3 ubiquitin protein ligase 2. | 0.540 |
Arrdc5 | Arrdc4 | ENSRNOP00000064476 | ENSRNOP00000073183 | Arrestin domain-containing 5. | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | 0.621 |
Arrdc5 | Nedd4 | ENSRNOP00000064476 | ENSRNOP00000074683 | Arrestin domain-containing 5. | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/K [...] | 0.734 |
Arrdc5 | Nedd4l | ENSRNOP00000064476 | ENSRNOP00000070352 | Arrestin domain-containing 5. | NEDD4-like E3 ubiquitin protein ligase. | 0.463 |
Arrdc5 | Wwp2 | ENSRNOP00000064476 | ENSRNOP00000018837 | Arrestin domain-containing 5. | WW domain-containing E3 ubiquitin protein ligase 2. | 0.678 |
Isoc1 | Arrdc4 | ENSRNOP00000026706 | ENSRNOP00000073183 | Isochorismatase domain-containing protein 1; Belongs to the isochorismatase family. | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | 0.516 |
Isoc1 | Samd12 | ENSRNOP00000026706 | ENSRNOP00000068526 | Isochorismatase domain-containing protein 1; Belongs to the isochorismatase family. | Sterile alpha motif domain-containing 12. | 0.646 |
Mlxip | Arrdc4 | ENSRNOP00000001690 | ENSRNOP00000073183 | MLX-interacting protein. | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | 0.574 |
Nedd4 | Arrdc4 | ENSRNOP00000074683 | ENSRNOP00000073183 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/K [...] | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. | 0.707 |
Nedd4 | Arrdc5 | ENSRNOP00000074683 | ENSRNOP00000064476 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/K [...] | Arrestin domain-containing 5. | 0.734 |
Nedd4 | Nedd4l | ENSRNOP00000074683 | ENSRNOP00000070352 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. Involved in the pathway leading to the degradation of VEGFR-2/K [...] | NEDD4-like E3 ubiquitin protein ligase. | 0.936 |