node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Crebbp | Stat1 | ENSRNOP00000007079 | ENSRNOP00000070183 | Histone lysine acetyltransferase CREBBP; Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (By similarity). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (By similarity). Acetylates [...] | Signal transducer and activator of transcription. | 0.993 |
Crebbp | Stat2 | ENSRNOP00000007079 | ENSRNOP00000075125 | Histone lysine acetyltransferase CREBBP; Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (By similarity). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (By similarity). Acetylates [...] | Signal transducer and activator of transcription. | 0.986 |
Crebbp | Stat3 | ENSRNOP00000007079 | ENSRNOP00000026760 | Histone lysine acetyltransferase CREBBP; Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (By similarity). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (By similarity). Acetylates [...] | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.979 |
Ifnar1 | Ifnar2 | ENSRNOP00000031611 | ENSRNOP00000065773 | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | Interferon alpha and beta receptor subunit 2. | 0.999 |
Ifnar1 | Irf9 | ENSRNOP00000031611 | ENSRNOP00000026364 | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | Interferon regulatory factor 9. | 0.906 |
Ifnar1 | Jak1 | ENSRNOP00000031611 | ENSRNOP00000061649 | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | Tyrosine-protein kinase. | 0.999 |
Ifnar1 | Jak2 | ENSRNOP00000031611 | ENSRNOP00000071877 | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.968 |
Ifnar1 | Jak3 | ENSRNOP00000031611 | ENSRNOP00000025312 | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | Tyrosine-protein kinase JAK3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails o [...] | 0.940 |
Ifnar1 | Stat1 | ENSRNOP00000031611 | ENSRNOP00000070183 | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | Signal transducer and activator of transcription. | 0.957 |
Ifnar1 | Stat2 | ENSRNOP00000031611 | ENSRNOP00000075125 | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | Signal transducer and activator of transcription. | 0.993 |
Ifnar1 | Stat3 | ENSRNOP00000031611 | ENSRNOP00000026760 | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.766 |
Ifnar1 | Tyk2 | ENSRNOP00000031611 | ENSRNOP00000048018 | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | Tyrosine-protein kinase. | 0.999 |
Ifnar2 | Ifnar1 | ENSRNOP00000065773 | ENSRNOP00000031611 | Interferon alpha and beta receptor subunit 2. | Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a. | 0.999 |
Ifnar2 | Irf9 | ENSRNOP00000065773 | ENSRNOP00000026364 | Interferon alpha and beta receptor subunit 2. | Interferon regulatory factor 9. | 0.794 |
Ifnar2 | Jak1 | ENSRNOP00000065773 | ENSRNOP00000061649 | Interferon alpha and beta receptor subunit 2. | Tyrosine-protein kinase. | 0.980 |
Ifnar2 | Jak2 | ENSRNOP00000065773 | ENSRNOP00000071877 | Interferon alpha and beta receptor subunit 2. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.944 |
Ifnar2 | Jak3 | ENSRNOP00000065773 | ENSRNOP00000025312 | Interferon alpha and beta receptor subunit 2. | Tyrosine-protein kinase JAK3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails o [...] | 0.933 |
Ifnar2 | Stat1 | ENSRNOP00000065773 | ENSRNOP00000070183 | Interferon alpha and beta receptor subunit 2. | Signal transducer and activator of transcription. | 0.920 |
Ifnar2 | Stat2 | ENSRNOP00000065773 | ENSRNOP00000075125 | Interferon alpha and beta receptor subunit 2. | Signal transducer and activator of transcription. | 0.983 |
Ifnar2 | Stat3 | ENSRNOP00000065773 | ENSRNOP00000026760 | Interferon alpha and beta receptor subunit 2. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.485 |