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Myo9b protein (Rattus norvegicus) - STRING interaction network
"Myo9b" - Unconventional myosin-IXb in Rattus norvegicus
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Myo9bUnconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (By similarity). Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase acti [...] (1988 aa)    
Predicted Functional Partners:
Rhoa
Transforming protein RhoA; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and a [...] (193 aa)
     
  0.974
Rhoc
Ras homolog family member C; Belongs to the small GTPase superfamily. Rho family (193 aa)
     
  0.967
Rac2
Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Belongs to the small GTPase superfamily. Rho family (192 aa)
     
  0.959
Rhof
Similar to ras homolog gene family, member f; Belongs to the small GTPase superfamily. Rho family (211 aa)
     
  0.951
Rhobtb1
Rho-related BTB domain containing 1 (694 aa)
     
  0.951
Rhob
Rho-related GTP-binding protein RhoB; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascul [...] (196 aa)
     
  0.951
Rac1
Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated [...] (192 aa)
     
  0.950
Rhog
Ras homolog family member G; Belongs to the small GTPase superfamily. Rho family (191 aa)
     
  0.949
Rhoh
Ras homolog family member H; Belongs to the small GTPase superfamily. Rho family (191 aa)
     
  0.949
Rhod
Ras homolog gene family, member D (Predicted), isoform CRA_b; Ras homolog family member D; Belongs to the small GTPase superfamily. Rho family (210 aa)
     
  0.947
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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