node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Eif3i | Eif4a1 | ENSRNOP00000067288 | ENSRNOP00000049419 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | 0.973 |
Eif3i | Eif4a2 | ENSRNOP00000067288 | ENSRNOP00000002484 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). | 0.920 |
Eif3i | Eif4b | ENSRNOP00000067288 | ENSRNOP00000014033 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Eukaryotic translation initiation factor 4B. | 0.645 |
Eif3i | Eif4e | ENSRNOP00000067288 | ENSRNOP00000073799 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Eukaryotic translation initiation factor 4E; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E- FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell [...] | 0.659 |
Eif3i | Eif4g1 | ENSRNOP00000067288 | ENSRNOP00000049629 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Eukaryotic translation initiation factor 4 gamma, 1. | 0.868 |
Eif3i | Eif4g2 | ENSRNOP00000067288 | ENSRNOP00000062967 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Eukaryotic translation initiation factor 4, gamma 2. | 0.701 |
Eif3i | Eif4g3 | ENSRNOP00000067288 | ENSRNOP00000070544 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Eukaryotic translation initiation factor 4 gamma, 3. | 0.743 |
Eif3i | Eif4h | ENSRNOP00000067288 | ENSRNOP00000043254 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). | 0.512 |
Eif3i | Paip1 | ENSRNOP00000067288 | ENSRNOP00000069568 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Poly(A)-binding protein-interacting protein 1. | 0.750 |
Eif4a1 | Eif3i | ENSRNOP00000049419 | ENSRNOP00000067288 | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 0.973 |
Eif4a1 | Eif4a2 | ENSRNOP00000049419 | ENSRNOP00000002484 | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). | 0.967 |
Eif4a1 | Eif4b | ENSRNOP00000049419 | ENSRNOP00000014033 | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | Eukaryotic translation initiation factor 4B. | 0.996 |
Eif4a1 | Eif4e | ENSRNOP00000049419 | ENSRNOP00000073799 | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | Eukaryotic translation initiation factor 4E; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E- FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell [...] | 0.990 |
Eif4a1 | Eif4g1 | ENSRNOP00000049419 | ENSRNOP00000049629 | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | Eukaryotic translation initiation factor 4 gamma, 1. | 0.998 |
Eif4a1 | Eif4g2 | ENSRNOP00000049419 | ENSRNOP00000062967 | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | Eukaryotic translation initiation factor 4, gamma 2. | 0.996 |
Eif4a1 | Eif4g3 | ENSRNOP00000049419 | ENSRNOP00000070544 | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | Eukaryotic translation initiation factor 4 gamma, 3. | 0.994 |
Eif4a1 | Eif4h | ENSRNOP00000049419 | ENSRNOP00000043254 | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). | 0.967 |
Eif4a1 | Paip1 | ENSRNOP00000049419 | ENSRNOP00000069568 | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | Poly(A)-binding protein-interacting protein 1. | 0.989 |
Eif4a1 | Pdcd4 | ENSRNOP00000049419 | ENSRNOP00000020155 | Eukaryotic translation initiation factor 4A1, isoform CRA_c; Belongs to the DEAD box helicase family. | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). Belongs to the PDCD4 family. | 0.980 |
Eif4a2 | Eif3i | ENSRNOP00000002484 | ENSRNOP00000067288 | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 0.920 |