node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cul1 | Cul4a | ENSRNOP00000007620 | ENSRNOP00000026653 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | RGD1563853 protein; Belongs to the cullin family. | 0.865 |
Cul1 | Cul4b | ENSRNOP00000007620 | ENSRNOP00000060639 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Cullin 4B (Predicted); Belongs to the cullin family. | 0.721 |
Cul1 | Ddb1 | ENSRNOP00000007620 | ENSRNOP00000028188 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] | 0.895 |
Cul1 | Fbxw5 | ENSRNOP00000007620 | ENSRNOP00000029229 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] | 0.873 |
Cul1 | Rbx1 | ENSRNOP00000007620 | ENSRNOP00000069049 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Ring-box 1. | 0.999 |
Cul1 | Skp1 | ENSRNOP00000007620 | ENSRNOP00000073214 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
Cul4a | Cul1 | ENSRNOP00000026653 | ENSRNOP00000007620 | RGD1563853 protein; Belongs to the cullin family. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.865 |
Cul4a | Cul4b | ENSRNOP00000026653 | ENSRNOP00000060639 | RGD1563853 protein; Belongs to the cullin family. | Cullin 4B (Predicted); Belongs to the cullin family. | 0.995 |
Cul4a | Dcaf1 | ENSRNOP00000026653 | ENSRNOP00000075456 | RGD1563853 protein; Belongs to the cullin family. | DDB1 and CUL4-associated factor 1. | 0.999 |
Cul4a | Dcaf6 | ENSRNOP00000026653 | ENSRNOP00000004199 | RGD1563853 protein; Belongs to the cullin family. | DDB1 and CUL4-associated factor 6. | 0.900 |
Cul4a | Dcaf8 | ENSRNOP00000026653 | ENSRNOP00000008944 | RGD1563853 protein; Belongs to the cullin family. | DDB1- and CUL4-associated factor 8; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF8 family. | 0.935 |
Cul4a | Ddb1 | ENSRNOP00000026653 | ENSRNOP00000028188 | RGD1563853 protein; Belongs to the cullin family. | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] | 0.999 |
Cul4a | Fbxw5 | ENSRNOP00000026653 | ENSRNOP00000029229 | RGD1563853 protein; Belongs to the cullin family. | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] | 0.910 |
Cul4a | Rbx1 | ENSRNOP00000026653 | ENSRNOP00000069049 | RGD1563853 protein; Belongs to the cullin family. | Ring-box 1. | 0.999 |
Cul4a | Skp1 | ENSRNOP00000026653 | ENSRNOP00000073214 | RGD1563853 protein; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.796 |
Cul4b | Cul1 | ENSRNOP00000060639 | ENSRNOP00000007620 | Cullin 4B (Predicted); Belongs to the cullin family. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.721 |
Cul4b | Cul4a | ENSRNOP00000060639 | ENSRNOP00000026653 | Cullin 4B (Predicted); Belongs to the cullin family. | RGD1563853 protein; Belongs to the cullin family. | 0.995 |
Cul4b | Dcaf1 | ENSRNOP00000060639 | ENSRNOP00000075456 | Cullin 4B (Predicted); Belongs to the cullin family. | DDB1 and CUL4-associated factor 1. | 0.996 |
Cul4b | Dcaf6 | ENSRNOP00000060639 | ENSRNOP00000004199 | Cullin 4B (Predicted); Belongs to the cullin family. | DDB1 and CUL4-associated factor 6. | 0.861 |
Cul4b | Dcaf8 | ENSRNOP00000060639 | ENSRNOP00000008944 | Cullin 4B (Predicted); Belongs to the cullin family. | DDB1- and CUL4-associated factor 8; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF8 family. | 0.890 |