node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Braf | Ksr1 | ENSRNOP00000014604 | ENSRNOP00000049882 | B-Raf proto-oncogene, serine/threonine kinase. | Kinase suppressor of ras 1 (Predicted). | 0.883 |
Braf | Ksr2 | ENSRNOP00000014604 | ENSRNOP00000041584 | B-Raf proto-oncogene, serine/threonine kinase. | Kinase suppressor of ras 2. | 0.680 |
Braf | Map2k1 | ENSRNOP00000014604 | ENSRNOP00000013933 | B-Raf proto-oncogene, serine/threonine kinase. | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | 0.996 |
Braf | Map2k2 | ENSRNOP00000014604 | ENSRNOP00000027272 | B-Raf proto-oncogene, serine/threonine kinase. | Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). | 0.911 |
Braf | Mapk3 | ENSRNOP00000014604 | ENSRNOP00000070784 | B-Raf proto-oncogene, serine/threonine kinase. | Mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.864 |
Braf | Mark3 | ENSRNOP00000014604 | ENSRNOP00000073297 | B-Raf proto-oncogene, serine/threonine kinase. | MAP/microtubule affinity-regulating kinase 3; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. | 0.436 |
Braf | Raf1 | ENSRNOP00000014604 | ENSRNOP00000013831 | B-Raf proto-oncogene, serine/threonine kinase. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.989 |
Cd209a | Ksr1 | ENSRNOP00000058440 | ENSRNOP00000049882 | CD209a antigen. | Kinase suppressor of ras 1 (Predicted). | 0.807 |
Cd209a | Lsp1 | ENSRNOP00000058440 | ENSRNOP00000051747 | CD209a antigen. | Lymphocyte specific 1, isoform CRA_a. | 0.967 |
Cd209a | Plk3 | ENSRNOP00000058440 | ENSRNOP00000025197 | CD209a antigen. | Serine/threonine-protein kinase PLK3; Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosi [...] | 0.653 |
Ksr1 | Braf | ENSRNOP00000049882 | ENSRNOP00000014604 | Kinase suppressor of ras 1 (Predicted). | B-Raf proto-oncogene, serine/threonine kinase. | 0.883 |
Ksr1 | Cd209a | ENSRNOP00000049882 | ENSRNOP00000058440 | Kinase suppressor of ras 1 (Predicted). | CD209a antigen. | 0.807 |
Ksr1 | Ksr2 | ENSRNOP00000049882 | ENSRNOP00000041584 | Kinase suppressor of ras 1 (Predicted). | Kinase suppressor of ras 2. | 0.928 |
Ksr1 | Lsp1 | ENSRNOP00000049882 | ENSRNOP00000051747 | Kinase suppressor of ras 1 (Predicted). | Lymphocyte specific 1, isoform CRA_a. | 0.990 |
Ksr1 | Map2k1 | ENSRNOP00000049882 | ENSRNOP00000013933 | Kinase suppressor of ras 1 (Predicted). | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | 0.976 |
Ksr1 | Map2k2 | ENSRNOP00000049882 | ENSRNOP00000027272 | Kinase suppressor of ras 1 (Predicted). | Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity). | 0.920 |
Ksr1 | Mapk3 | ENSRNOP00000049882 | ENSRNOP00000070784 | Kinase suppressor of ras 1 (Predicted). | Mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.756 |
Ksr1 | Mark3 | ENSRNOP00000049882 | ENSRNOP00000073297 | Kinase suppressor of ras 1 (Predicted). | MAP/microtubule affinity-regulating kinase 3; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. | 0.917 |
Ksr1 | Plk3 | ENSRNOP00000049882 | ENSRNOP00000025197 | Kinase suppressor of ras 1 (Predicted). | Serine/threonine-protein kinase PLK3; Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosi [...] | 0.948 |
Ksr1 | Raf1 | ENSRNOP00000049882 | ENSRNOP00000013831 | Kinase suppressor of ras 1 (Predicted). | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.982 |