node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bmyc | Cul1 | ENSRNOP00000059721 | ENSRNOP00000007620 | Protein B-Myc; Seems to act as an inhibitor of cellular proliferation. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.589 |
Bmyc | Fbxw7 | ENSRNOP00000059721 | ENSRNOP00000050193 | Protein B-Myc; Seems to act as an inhibitor of cellular proliferation. | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and probably PSEN1 (By similarity). Acts as a nega [...] | 0.972 |
Bmyc | Jun | ENSRNOP00000059721 | ENSRNOP00000011732 | Protein B-Myc; Seems to act as an inhibitor of cellular proliferation. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter. | 0.765 |
Bmyc | Notch1 | ENSRNOP00000059721 | ENSRNOP00000026212 | Protein B-Myc; Seems to act as an inhibitor of cellular proliferation. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (By similarity). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (By similarity). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in angiogenesis; negatively regulates endothelial cell proliferation and mig [...] | 0.420 |
Bmyc | Rbx1 | ENSRNOP00000059721 | ENSRNOP00000069049 | Protein B-Myc; Seems to act as an inhibitor of cellular proliferation. | Ring-box 1. | 0.405 |
Bmyc | Skp1 | ENSRNOP00000059721 | ENSRNOP00000073214 | Protein B-Myc; Seems to act as an inhibitor of cellular proliferation. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.864 |
Bmyc | Skp2 | ENSRNOP00000059721 | ENSRNOP00000074788 | Protein B-Myc; Seems to act as an inhibitor of cellular proliferation. | S-phase kinase-associated protein 2 (P45). | 0.751 |
Btrc | Ccne1 | ENSRNOP00000022426 | ENSRNOP00000020014 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. | 0.500 |
Btrc | Cul1 | ENSRNOP00000022426 | ENSRNOP00000007620 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.999 |
Btrc | Fbxo4 | ENSRNOP00000022426 | ENSRNOP00000020925 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | F-box only protein 4 (Predicted). | 0.942 |
Btrc | Fbxw7 | ENSRNOP00000022426 | ENSRNOP00000050193 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and probably PSEN1 (By similarity). Acts as a nega [...] | 0.974 |
Btrc | Jun | ENSRNOP00000022426 | ENSRNOP00000011732 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter. | 0.587 |
Btrc | Rbx1 | ENSRNOP00000022426 | ENSRNOP00000069049 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | Ring-box 1. | 0.998 |
Btrc | Skp1 | ENSRNOP00000022426 | ENSRNOP00000073214 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
Btrc | Skp2 | ENSRNOP00000022426 | ENSRNOP00000074788 | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | S-phase kinase-associated protein 2 (P45). | 0.977 |
Ccne1 | Btrc | ENSRNOP00000020014 | ENSRNOP00000022426 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. | Beta-transducin repeat-containing E3 ubiquitin protein ligase. | 0.500 |
Ccne1 | Cul1 | ENSRNOP00000020014 | ENSRNOP00000007620 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.975 |
Ccne1 | Fbxw7 | ENSRNOP00000020014 | ENSRNOP00000050193 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and probably PSEN1 (By similarity). Acts as a nega [...] | 0.986 |
Ccne1 | Jun | ENSRNOP00000020014 | ENSRNOP00000011732 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter. | 0.619 |
Ccne1 | Notch1 | ENSRNOP00000020014 | ENSRNOP00000026212 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (By similarity). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (By similarity). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in angiogenesis; negatively regulates endothelial cell proliferation and mig [...] | 0.702 |