node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Alk | Egfr | ENSRNOP00000011630 | ENSRNOP00000006087 | Tyrosine-protein kinase receptor. | Receptor protein-tyrosine kinase. | 0.549 |
Alk | Eml4 | ENSRNOP00000011630 | ENSRNOP00000072435 | Tyrosine-protein kinase receptor. | EMAP-like 4. | 0.964 |
Alk | Kif5b | ENSRNOP00000011630 | ENSRNOP00000023860 | Tyrosine-protein kinase receptor. | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. | 0.710 |
Alk | Kras | ENSRNOP00000011630 | ENSRNOP00000012588 | Tyrosine-protein kinase receptor. | GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity). | 0.819 |
Alk | Ranbp2 | ENSRNOP00000011630 | ENSRNOP00000063941 | Tyrosine-protein kinase receptor. | RAN-binding protein 2. | 0.403 |
Alk | Ret | ENSRNOP00000011630 | ENSRNOP00000047793 | Tyrosine-protein kinase receptor. | Extracellular cell-membrane anchored RET cadherin 120 kDa fragment; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and [...] | 0.617 |
Alk | Ros1 | ENSRNOP00000011630 | ENSRNOP00000068996 | Tyrosine-protein kinase receptor. | Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...] | 0.494 |
Bub1 | Eml4 | ENSRNOP00000042114 | ENSRNOP00000072435 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | EMAP-like 4. | 0.695 |
Bub1 | Mad2l1 | ENSRNOP00000042114 | ENSRNOP00000007285 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | MAD2 (Mitotic arrest deficient, homolog)-like 1 (Yeast) (Predicted), isoform CRA_a. | 0.998 |
Bub1 | Plk1 | ENSRNOP00000042114 | ENSRNOP00000025629 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] | 0.980 |
Egfr | Alk | ENSRNOP00000006087 | ENSRNOP00000011630 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase receptor. | 0.549 |
Egfr | Eml4 | ENSRNOP00000006087 | ENSRNOP00000072435 | Receptor protein-tyrosine kinase. | EMAP-like 4. | 0.780 |
Egfr | Kif5b | ENSRNOP00000006087 | ENSRNOP00000023860 | Receptor protein-tyrosine kinase. | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. | 0.410 |
Egfr | Kras | ENSRNOP00000006087 | ENSRNOP00000012588 | Receptor protein-tyrosine kinase. | GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity). | 0.961 |
Egfr | Ret | ENSRNOP00000006087 | ENSRNOP00000047793 | Receptor protein-tyrosine kinase. | Extracellular cell-membrane anchored RET cadherin 120 kDa fragment; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and [...] | 0.572 |
Egfr | Ros1 | ENSRNOP00000006087 | ENSRNOP00000068996 | Receptor protein-tyrosine kinase. | Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...] | 0.510 |
Eml4 | Alk | ENSRNOP00000072435 | ENSRNOP00000011630 | EMAP-like 4. | Tyrosine-protein kinase receptor. | 0.964 |
Eml4 | Bub1 | ENSRNOP00000072435 | ENSRNOP00000042114 | EMAP-like 4. | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | 0.695 |
Eml4 | Egfr | ENSRNOP00000072435 | ENSRNOP00000006087 | EMAP-like 4. | Receptor protein-tyrosine kinase. | 0.780 |
Eml4 | Kif5b | ENSRNOP00000072435 | ENSRNOP00000023860 | EMAP-like 4. | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. | 0.709 |