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Srr protein (Rattus norvegicus) - STRING interaction network
"Srr" - Serine racemase in Rattus norvegicus
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SrrSerine racemase; Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (333 aa)    
Predicted Functional Partners:
Shmt1
Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family (681 aa)
     
 
  0.961
Shmt2
Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family (504 aa)
     
 
  0.957
Psph
Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity) (225 aa)
   
 
  0.945
Sds
L-serine dehydratase/L-threonine deaminase; Serine dehydratase; Belongs to the serine/threonine dehydratase family (362 aa)
   
   
0.933
Dao
D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (346 aa)
   
 
  0.931
Agxt
Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes) (414 aa)
   
  0.923
Cbs
Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L- homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (561 aa)
   
 
0.923
Sdsl
Serine dehydratase-like (358 aa)
   
   
0.918
Sptlc2
Serine palmitoyltransferase, long chain base subunit 2 (560 aa)
   
  0.826
Sptlc3
Serine palmitoyltransferase, long chain base subunit 3 (563 aa)
   
  0.826
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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