node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acsl4 | Ascl4 | ENSRNOP00000026057 | ENSRNOP00000051020 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs. Modulates prostaglandin E2 secretion (By similarity). | Achaete-scute family bHLH transcription factor 4. | 0.764 |
Acsl4 | Gpx4 | ENSRNOP00000026057 | ENSRNOP00000076309 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs. Modulates prostaglandin E2 secretion (By similarity). | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non- apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). T [...] | 0.809 |
Arhgap42 | Ascl4 | ENSRNOP00000037659 | ENSRNOP00000051020 | Rho GTPase-activating protein 42. | Achaete-scute family bHLH transcription factor 4. | 0.406 |
Arhgap42 | Maip1 | ENSRNOP00000037659 | ENSRNOP00000021533 | Rho GTPase-activating protein 42. | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | 0.447 |
Arhgap42 | Nepro | ENSRNOP00000037659 | ENSRNOP00000018474 | Rho GTPase-activating protein 42. | Nucleolus and neural progenitor protein. | 0.441 |
Ascl4 | Acsl4 | ENSRNOP00000051020 | ENSRNOP00000026057 | Achaete-scute family bHLH transcription factor 4. | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs. Modulates prostaglandin E2 secretion (By similarity). | 0.764 |
Ascl4 | Arhgap42 | ENSRNOP00000051020 | ENSRNOP00000037659 | Achaete-scute family bHLH transcription factor 4. | Rho GTPase-activating protein 42. | 0.406 |
Ascl4 | Bhlhe23 | ENSRNOP00000051020 | ENSRNOP00000013690 | Achaete-scute family bHLH transcription factor 4. | Similar to basic helix-loop-helix transcriptional regulator beta4 (Predicted). | 0.505 |
Ascl4 | Gpx4 | ENSRNOP00000051020 | ENSRNOP00000076309 | Achaete-scute family bHLH transcription factor 4. | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non- apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). T [...] | 0.525 |
Ascl4 | Maip1 | ENSRNOP00000051020 | ENSRNOP00000021533 | Achaete-scute family bHLH transcription factor 4. | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | 0.408 |
Ascl4 | Nepro | ENSRNOP00000051020 | ENSRNOP00000018474 | Achaete-scute family bHLH transcription factor 4. | Nucleolus and neural progenitor protein. | 0.410 |
Ascl4 | Phf24 | ENSRNOP00000051020 | ENSRNOP00000000141 | Achaete-scute family bHLH transcription factor 4. | PHD finger protein 24. | 0.594 |
Ascl4 | Tcf12 | ENSRNOP00000051020 | ENSRNOP00000074384 | Achaete-scute family bHLH transcription factor 4. | Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). | 0.411 |
Ascl4 | Tcf24 | ENSRNOP00000051020 | ENSRNOP00000069940 | Achaete-scute family bHLH transcription factor 4. | Transcription factor 24. | 0.588 |
Ascl4 | Tcf4 | ENSRNOP00000051020 | ENSRNOP00000070021 | Achaete-scute family bHLH transcription factor 4. | Transcription factor 4; Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Interacts with the CCAAT displacement protein (CDP2) to bind the tyrosine hydroxylase enhancer. | 0.411 |
Bhlhe23 | Ascl4 | ENSRNOP00000013690 | ENSRNOP00000051020 | Similar to basic helix-loop-helix transcriptional regulator beta4 (Predicted). | Achaete-scute family bHLH transcription factor 4. | 0.505 |
Bhlhe23 | Tcf24 | ENSRNOP00000013690 | ENSRNOP00000069940 | Similar to basic helix-loop-helix transcriptional regulator beta4 (Predicted). | Transcription factor 24. | 0.593 |
Gpx4 | Acsl4 | ENSRNOP00000076309 | ENSRNOP00000026057 | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non- apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). T [...] | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs. Modulates prostaglandin E2 secretion (By similarity). | 0.809 |
Gpx4 | Ascl4 | ENSRNOP00000076309 | ENSRNOP00000051020 | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non- apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). T [...] | Achaete-scute family bHLH transcription factor 4. | 0.525 |
Maip1 | Arhgap42 | ENSRNOP00000021533 | ENSRNOP00000037659 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | Rho GTPase-activating protein 42. | 0.447 |