node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amot | Amotl2 | ENSRNOP00000070184 | ENSRNOP00000075540 | Angiomotin. | Angiomotin-like protein 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity); Belongs to the angiomotin family. | 0.942 |
Amot | Crb3 | ENSRNOP00000070184 | ENSRNOP00000070535 | Angiomotin. | Crumbs homolog 3 (Drosophila), isoform CRA_b. | 0.664 |
Amot | Mpdz | ENSRNOP00000070184 | ENSRNOP00000072433 | Angiomotin. | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. | 0.972 |
Amot | Mpp5 | ENSRNOP00000070184 | ENSRNOP00000012005 | Angiomotin. | MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required [...] | 0.994 |
Amot | Patj | ENSRNOP00000070184 | ENSRNOP00000010211 | Angiomotin. | InaD-like protein; Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (By similarity). | 0.999 |
Amotl2 | Amot | ENSRNOP00000075540 | ENSRNOP00000070184 | Angiomotin-like protein 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity); Belongs to the angiomotin family. | Angiomotin. | 0.942 |
Amotl2 | Mpdz | ENSRNOP00000075540 | ENSRNOP00000072433 | Angiomotin-like protein 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity); Belongs to the angiomotin family. | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. | 0.933 |
Amotl2 | Mpp5 | ENSRNOP00000075540 | ENSRNOP00000012005 | Angiomotin-like protein 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity); Belongs to the angiomotin family. | MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required [...] | 0.559 |
Amotl2 | Patj | ENSRNOP00000075540 | ENSRNOP00000010211 | Angiomotin-like protein 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity); Belongs to the angiomotin family. | InaD-like protein; Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (By similarity). | 0.952 |
Crb1 | Crb2 | ENSRNOP00000037018 | ENSRNOP00000035420 | Crumbs homolog 1 (Drosophila) (Predicted). | Crumbs cell polarity complex component 2. | 0.914 |
Crb1 | Crb3 | ENSRNOP00000037018 | ENSRNOP00000070535 | Crumbs homolog 1 (Drosophila) (Predicted). | Crumbs homolog 3 (Drosophila), isoform CRA_b. | 0.896 |
Crb1 | LOC102556347 | ENSRNOP00000037018 | ENSRNOP00000064050 | Crumbs homolog 1 (Drosophila) (Predicted). | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | 0.740 |
Crb1 | Mpdz | ENSRNOP00000037018 | ENSRNOP00000072433 | Crumbs homolog 1 (Drosophila) (Predicted). | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. | 0.812 |
Crb1 | Mpp5 | ENSRNOP00000037018 | ENSRNOP00000012005 | Crumbs homolog 1 (Drosophila) (Predicted). | MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required [...] | 0.942 |
Crb1 | Patj | ENSRNOP00000037018 | ENSRNOP00000010211 | Crumbs homolog 1 (Drosophila) (Predicted). | InaD-like protein; Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (By similarity). | 0.976 |
Crb2 | Crb1 | ENSRNOP00000035420 | ENSRNOP00000037018 | Crumbs cell polarity complex component 2. | Crumbs homolog 1 (Drosophila) (Predicted). | 0.914 |
Crb2 | Crb3 | ENSRNOP00000035420 | ENSRNOP00000070535 | Crumbs cell polarity complex component 2. | Crumbs homolog 3 (Drosophila), isoform CRA_b. | 0.927 |
Crb2 | LOC102556347 | ENSRNOP00000035420 | ENSRNOP00000064050 | Crumbs cell polarity complex component 2. | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | 0.743 |
Crb2 | Mpdz | ENSRNOP00000035420 | ENSRNOP00000072433 | Crumbs cell polarity complex component 2. | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. | 0.808 |
Crb2 | Mpp5 | ENSRNOP00000035420 | ENSRNOP00000012005 | Crumbs cell polarity complex component 2. | MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required [...] | 0.885 |