node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gpr143 | Mlana | ENSRNOP00000004758 | ENSRNOP00000074189 | G protein-coupled receptor 143 (Predicted). | Melan-A (Predicted), isoform CRA_a. | 0.676 |
Gpr143 | Rab27a | ENSRNOP00000004758 | ENSRNOP00000068946 | G protein-coupled receptor 143 (Predicted). | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.468 |
Gpr143 | Slc24a5 | ENSRNOP00000004758 | ENSRNOP00000048644 | G protein-coupled receptor 143 (Predicted). | Solute carrier family 24, member 5 (Predicted); Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.576 |
Gpr143 | Slc45a2 | ENSRNOP00000004758 | ENSRNOP00000025490 | G protein-coupled receptor 143 (Predicted). | Solute carrier family 45, member 2 (Predicted). | 0.675 |
Gpr143 | Tyr | ENSRNOP00000004758 | ENSRNOP00000021971 | G protein-coupled receptor 143 (Predicted). | Tyrosinase (Albino coat color) (Mapped), isoform CRA_a. | 0.700 |
Gpr143 | Tyrp1 | ENSRNOP00000004758 | ENSRNOP00000041764 | G protein-coupled receptor 143 (Predicted). | Tyrosinase-related protein 1. | 0.709 |
Mitf | Mlana | ENSRNOP00000044350 | ENSRNOP00000074189 | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] | Melan-A (Predicted), isoform CRA_a. | 0.579 |
Mitf | Slc24a5 | ENSRNOP00000044350 | ENSRNOP00000048644 | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] | Solute carrier family 24, member 5 (Predicted); Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.461 |
Mitf | Slc45a2 | ENSRNOP00000044350 | ENSRNOP00000025490 | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] | Solute carrier family 45, member 2 (Predicted). | 0.465 |
Mitf | Sox10 | ENSRNOP00000044350 | ENSRNOP00000015283 | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). | 0.653 |
Mitf | Tyr | ENSRNOP00000044350 | ENSRNOP00000021971 | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] | Tyrosinase (Albino coat color) (Mapped), isoform CRA_a. | 0.865 |
Mitf | Tyrp1 | ENSRNOP00000044350 | ENSRNOP00000041764 | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] | Tyrosinase-related protein 1. | 0.874 |
Mlana | Gpr143 | ENSRNOP00000074189 | ENSRNOP00000004758 | Melan-A (Predicted), isoform CRA_a. | G protein-coupled receptor 143 (Predicted). | 0.676 |
Mlana | Mitf | ENSRNOP00000074189 | ENSRNOP00000044350 | Melan-A (Predicted), isoform CRA_a. | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] | 0.579 |
Mlana | RT1-DOa | ENSRNOP00000074189 | ENSRNOP00000034452 | Melan-A (Predicted), isoform CRA_a. | RT1 class II, locus DOa; Belongs to the MHC class II family. | 0.598 |
Mlana | RT1-Da | ENSRNOP00000074189 | ENSRNOP00000048774 | Melan-A (Predicted), isoform CRA_a. | Histocompatibility 2, class II antigen E alpha; Belongs to the MHC class II family. | 0.728 |
Mlana | Rab27a | ENSRNOP00000074189 | ENSRNOP00000068946 | Melan-A (Predicted), isoform CRA_a. | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.597 |
Mlana | Slc24a5 | ENSRNOP00000074189 | ENSRNOP00000048644 | Melan-A (Predicted), isoform CRA_a. | Solute carrier family 24, member 5 (Predicted); Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.561 |
Mlana | Slc45a2 | ENSRNOP00000074189 | ENSRNOP00000025490 | Melan-A (Predicted), isoform CRA_a. | Solute carrier family 45, member 2 (Predicted). | 0.621 |
Mlana | Sox10 | ENSRNOP00000074189 | ENSRNOP00000015283 | Melan-A (Predicted), isoform CRA_a. | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). | 0.702 |