STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nap1l4Nucleosome assembly protein 1-like 4; Acts as histone chaperone in nucleosome assembly. (387 aa)    
Predicted Functional Partners:
Slc22a18
Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (By similarity). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
      
 0.748
Phlda2
Pleckstrin homology-like domain, family A, member 2.
      
 0.705
Osbpl5
Oxysterol-binding protein; Belongs to the OSBP family.
      
 0.696
Mindy3
Similar to RIKEN cDNA 2310047O13 (Predicted).
      
 0.627
Tssc4
Protein TSSC4; Belongs to the TSSC4 family.
   
  
 0.606
Shisa4
Transmembrane protein 58 (Predicted).
   
 
 0.589
Cars
Cysteinyl-tRNA synthetase (Predicted), isoform CRA_b.
      
 0.587
H2az1
Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...]
   
 
 0.576
M0R6X5_RAT
Histone H2A; Belongs to the histone H2A family.
    
 
 0.567
H2az2
Histone H2A; Belongs to the histone H2A family.
    
 
 0.567
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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