node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdc42bpg | Rab40b | ENSRNOP00000029466 | ENSRNOP00000051800 | CDC42 binding protein kinase gamma (DMPK-like) (Predicted); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Rab40b, member RAS oncogene family (Predicted). | 0.522 |
Cdc42bpg | Rabl3 | ENSRNOP00000029466 | ENSRNOP00000033847 | CDC42 binding protein kinase gamma (DMPK-like) (Predicted); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | RAB, member of RAS oncogene family-like 3 (Predicted), isoform CRA_a. | 0.525 |
Chm | Rab40b | ENSRNOP00000000174 | ENSRNOP00000051800 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | Rab40b, member RAS oncogene family (Predicted). | 0.527 |
Chm | Rabggta | ENSRNOP00000000174 | ENSRNOP00000049261 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. | 0.996 |
Chm | Rabggtb | ENSRNOP00000000174 | ENSRNOP00000061541 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Belongs to the protein prenyltransferase subunit beta family. | 0.992 |
Cul5 | Rab40b | ENSRNOP00000010956 | ENSRNOP00000051800 | Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] | Rab40b, member RAS oncogene family (Predicted). | 0.623 |
Mthfsd | Rab40b | ENSRNOP00000064613 | ENSRNOP00000051800 | Methenyltetrahydrofolate synthetase domain containing. | Rab40b, member RAS oncogene family (Predicted). | 0.608 |
Mthfsd | Utp15 | ENSRNOP00000064613 | ENSRNOP00000022259 | Methenyltetrahydrofolate synthetase domain containing. | U3 small nucleolar RNA-associated protein 15 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. | 0.771 |
Mthfsd | Wdr6 | ENSRNOP00000064613 | ENSRNOP00000027411 | Methenyltetrahydrofolate synthetase domain containing. | WD repeat-containing protein 6; Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy; Belongs to the WD repeat WDR6 family. | 0.685 |
Rab40b | Cdc42bpg | ENSRNOP00000051800 | ENSRNOP00000029466 | Rab40b, member RAS oncogene family (Predicted). | CDC42 binding protein kinase gamma (DMPK-like) (Predicted); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.522 |
Rab40b | Chm | ENSRNOP00000051800 | ENSRNOP00000000174 | Rab40b, member RAS oncogene family (Predicted). | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | 0.527 |
Rab40b | Cul5 | ENSRNOP00000051800 | ENSRNOP00000010956 | Rab40b, member RAS oncogene family (Predicted). | Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] | 0.623 |
Rab40b | Mthfsd | ENSRNOP00000051800 | ENSRNOP00000064613 | Rab40b, member RAS oncogene family (Predicted). | Methenyltetrahydrofolate synthetase domain containing. | 0.608 |
Rab40b | Rabggta | ENSRNOP00000051800 | ENSRNOP00000049261 | Rab40b, member RAS oncogene family (Predicted). | Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. | 0.548 |
Rab40b | Rabggtb | ENSRNOP00000051800 | ENSRNOP00000061541 | Rab40b, member RAS oncogene family (Predicted). | Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Belongs to the protein prenyltransferase subunit beta family. | 0.622 |
Rab40b | Rabl3 | ENSRNOP00000051800 | ENSRNOP00000033847 | Rab40b, member RAS oncogene family (Predicted). | RAB, member of RAS oncogene family-like 3 (Predicted), isoform CRA_a. | 0.596 |
Rab40b | Rilpl2 | ENSRNOP00000051800 | ENSRNOP00000001403 | Rab40b, member RAS oncogene family (Predicted). | RILP-like protein 2; Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). May function via activation of RAC1 and PAK1. | 0.656 |
Rab40b | Utp15 | ENSRNOP00000051800 | ENSRNOP00000022259 | Rab40b, member RAS oncogene family (Predicted). | U3 small nucleolar RNA-associated protein 15 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. | 0.554 |
Rab40b | Wdr6 | ENSRNOP00000051800 | ENSRNOP00000027411 | Rab40b, member RAS oncogene family (Predicted). | WD repeat-containing protein 6; Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy; Belongs to the WD repeat WDR6 family. | 0.563 |
Rabggta | Chm | ENSRNOP00000049261 | ENSRNOP00000000174 | Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | 0.996 |