STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Krt77Keratin, type II cytoskeletal 1b; Belongs to the intermediate filament family. (579 aa)    
Predicted Functional Partners:
Krt1
Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity).
  
0.656
Tmprss11b
Transmembrane protease serine 11B-like protein; Serine protease.
   
 
 0.613
Prr9
Proline-rich 9.
      
 0.563
Tmprss11c
Transmembrane protease serine; Belongs to the peptidase S1 family.
   
 
 0.560
rCG_40975
Small proline-rich protein 4.
   
  
 0.556
Lce1m
Late cornified envelope 1M.
   
  
 0.546
Krt79
Keratin 79; Belongs to the intermediate filament family.
  
0.534
Tlcd3b
TLC domain-containing 3B.
    
 
 0.531
Chd7
Chromodomain helicase DNA-binding protein 7.
    
 
 0.515
Krtap11-1
Keratin-associated protein 11-1.
   
  
 0.509
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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