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Slc10a2 protein (Rattus norvegicus) - STRING interaction network
"Slc10a2" - Ileal sodium/bile acid cotransporter in Rattus norvegicus
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Predicted Interactions
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textmining
co-expression
protein homology
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Slc10a2Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity); Belongs to the bile acid-sodium symporter (BASS) (TC 2.A.28) family (306 aa)    
Predicted Functional Partners:
Fabp6
Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion (By similarity); Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family (128 aa)
     
 
  0.981
Slc51a
Similar to RIKEN cDNA D630035O19 (Predicted), isoform CRA_b; Solute carrier family 51, alpha subunit (340 aa)
           
  0.830
Cyp7a1
Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Belongs to the cytochrome P450 family (503 aa)
     
   
  0.806
Abcb11
Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily (1321 aa)
     
   
  0.804
Slc51b
Solute carrier family 51, beta subunit (127 aa)
     
   
  0.757
Cyp8b1
Cytochrome P450, family 8, subfamily b, polypeptide 1 (499 aa)
     
   
  0.731
Nr0b2
Nuclear receptor subfamily 0 group B member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (260 aa)
     
   
  0.724
Tmigd1
Transmembrane and immunoglobulin domain containing 1 (261 aa)
     
   
  0.724
Nr1h4
Bile acid receptor; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5’- AGGTCA-3’ in w [...] (469 aa)
     
   
  0.707
Slc10a7
Sodium/bile acid cotransporter 7; Solute carrier family 10, member 7 (340 aa)
           
  0.701
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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