node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A0G2K1P7_RAT | Schip1 | ENSRNOP00000071929 | ENSRNOP00000054283 | IQCJ-SCHIP1 domain-containing protein. | Schwannomin-interacting protein 1. | 0.573 |
Frmpd3 | Schip1 | ENSRNOP00000074886 | ENSRNOP00000054283 | FERM domain-containing protein. | Schwannomin-interacting protein 1. | 0.439 |
Larp4b | Schip1 | ENSRNOP00000055347 | ENSRNOP00000054283 | La ribonucleoprotein 4B. | Schwannomin-interacting protein 1. | 0.440 |
Mlf1 | Schip1 | ENSRNOP00000017151 | ENSRNOP00000054283 | Myeloid leukemia factor 1 (Predicted), isoform CRA_a. | Schwannomin-interacting protein 1. | 0.506 |
Nf2 | Schip1 | ENSRNOP00000010690 | ENSRNOP00000054283 | Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] | Schwannomin-interacting protein 1. | 0.564 |
Nf2 | Taok1 | ENSRNOP00000010690 | ENSRNOP00000021368 | Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] | Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK1 [...] | 0.420 |
Prss53 | Schip1 | ENSRNOP00000033673 | ENSRNOP00000054283 | Similar to BC039632 protein (Predicted), isoform CRA_a; Belongs to the peptidase S1 family. | Schwannomin-interacting protein 1. | 0.447 |
RGD1559962 | Schip1 | ENSRNOP00000060587 | ENSRNOP00000054283 | Similar to High mobility group protein 2 (HMG-2). | Schwannomin-interacting protein 1. | 0.513 |
Schip1 | A0A0G2K1P7_RAT | ENSRNOP00000054283 | ENSRNOP00000071929 | Schwannomin-interacting protein 1. | IQCJ-SCHIP1 domain-containing protein. | 0.573 |
Schip1 | Frmpd3 | ENSRNOP00000054283 | ENSRNOP00000074886 | Schwannomin-interacting protein 1. | FERM domain-containing protein. | 0.439 |
Schip1 | Larp4b | ENSRNOP00000054283 | ENSRNOP00000055347 | Schwannomin-interacting protein 1. | La ribonucleoprotein 4B. | 0.440 |
Schip1 | Mlf1 | ENSRNOP00000054283 | ENSRNOP00000017151 | Schwannomin-interacting protein 1. | Myeloid leukemia factor 1 (Predicted), isoform CRA_a. | 0.506 |
Schip1 | Nf2 | ENSRNOP00000054283 | ENSRNOP00000010690 | Schwannomin-interacting protein 1. | Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] | 0.564 |
Schip1 | Prss53 | ENSRNOP00000054283 | ENSRNOP00000033673 | Schwannomin-interacting protein 1. | Similar to BC039632 protein (Predicted), isoform CRA_a; Belongs to the peptidase S1 family. | 0.447 |
Schip1 | RGD1559962 | ENSRNOP00000054283 | ENSRNOP00000060587 | Schwannomin-interacting protein 1. | Similar to High mobility group protein 2 (HMG-2). | 0.513 |
Schip1 | Taok1 | ENSRNOP00000054283 | ENSRNOP00000021368 | Schwannomin-interacting protein 1. | Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK1 [...] | 0.719 |
Schip1 | Taok2 | ENSRNOP00000054283 | ENSRNOP00000071896 | Schwannomin-interacting protein 1. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.618 |
Schip1 | Zfand5 | ENSRNOP00000054283 | ENSRNOP00000024583 | Schwannomin-interacting protein 1. | AN1-type zinc finger protein 5; Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent [...] | 0.686 |
Taok1 | Nf2 | ENSRNOP00000021368 | ENSRNOP00000010690 | Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK1 [...] | Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] | 0.420 |
Taok1 | Schip1 | ENSRNOP00000021368 | ENSRNOP00000054283 | Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK1 [...] | Schwannomin-interacting protein 1. | 0.719 |