node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atg14 | Pik3c3 | ENSRNOP00000016274 | ENSRNOP00000060791 | Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans- Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1- dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t [...] | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to [...] | 0.999 |
Atg14 | Pirt | ENSRNOP00000016274 | ENSRNOP00000054311 | Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans- Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1- dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t [...] | Phosphoinositide-interacting regulator of transient receptor potential channels. | 0.551 |
Atg14 | Wipi2 | ENSRNOP00000016274 | ENSRNOP00000001476 | Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans- Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1- dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t [...] | WD repeat domain phosphoinositide-interacting protein 2; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 [...] | 0.931 |
Dgkh | Phf24 | ENSRNOP00000054887 | ENSRNOP00000000141 | Diacylglycerol kinase. | PHD finger protein 24. | 0.448 |
Dgkh | Pirt | ENSRNOP00000054887 | ENSRNOP00000054311 | Diacylglycerol kinase. | Phosphoinositide-interacting regulator of transient receptor potential channels. | 0.403 |
Lmbrd2 | Pirt | ENSRNOP00000074034 | ENSRNOP00000054311 | Similar to RIKEN cDNA 9930036E21 gene (Predicted). | Phosphoinositide-interacting regulator of transient receptor potential channels. | 0.571 |
Phf24 | Dgkh | ENSRNOP00000000141 | ENSRNOP00000054887 | PHD finger protein 24. | Diacylglycerol kinase. | 0.448 |
Phf24 | Pirt | ENSRNOP00000000141 | ENSRNOP00000054311 | PHD finger protein 24. | Phosphoinositide-interacting regulator of transient receptor potential channels. | 0.606 |
Pik3c3 | Atg14 | ENSRNOP00000060791 | ENSRNOP00000016274 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to [...] | Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans- Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1- dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t [...] | 0.999 |
Pik3c3 | Pirt | ENSRNOP00000060791 | ENSRNOP00000054311 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to [...] | Phosphoinositide-interacting regulator of transient receptor potential channels. | 0.553 |
Pik3c3 | Wipi2 | ENSRNOP00000060791 | ENSRNOP00000001476 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to [...] | WD repeat domain phosphoinositide-interacting protein 2; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 [...] | 0.953 |
Pirt | Atg14 | ENSRNOP00000054311 | ENSRNOP00000016274 | Phosphoinositide-interacting regulator of transient receptor potential channels. | Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans- Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1- dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t [...] | 0.551 |
Pirt | Dgkh | ENSRNOP00000054311 | ENSRNOP00000054887 | Phosphoinositide-interacting regulator of transient receptor potential channels. | Diacylglycerol kinase. | 0.403 |
Pirt | Lmbrd2 | ENSRNOP00000054311 | ENSRNOP00000074034 | Phosphoinositide-interacting regulator of transient receptor potential channels. | Similar to RIKEN cDNA 9930036E21 gene (Predicted). | 0.571 |
Pirt | Phf24 | ENSRNOP00000054311 | ENSRNOP00000000141 | Phosphoinositide-interacting regulator of transient receptor potential channels. | PHD finger protein 24. | 0.606 |
Pirt | Pik3c3 | ENSRNOP00000054311 | ENSRNOP00000060791 | Phosphoinositide-interacting regulator of transient receptor potential channels. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to [...] | 0.553 |
Pirt | Rasd2 | ENSRNOP00000054311 | ENSRNOP00000020017 | Phosphoinositide-interacting regulator of transient receptor potential channels. | GTP-binding protein Rhes; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. | 0.537 |
Pirt | Stard10 | ENSRNOP00000054311 | ENSRNOP00000075607 | Phosphoinositide-interacting regulator of transient receptor potential channels. | StAR-related lipid transfer domain-containing 10. | 0.801 |
Pirt | Trarg1 | ENSRNOP00000054311 | ENSRNOP00000069416 | Phosphoinositide-interacting regulator of transient receptor potential channels. | Trafficking regulator of GLUT4 1; Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. Belongs to the CD225/Dispanin family. | 0.437 |
Pirt | Trpv1 | ENSRNOP00000054311 | ENSRNOP00000026493 | Phosphoinositide-interacting regulator of transient receptor potential channels. | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] | 0.638 |