node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atp6v0c | Grina | ENSRNOP00000008736 | ENSRNOP00000056356 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | 0.466 |
Cyhr1 | Grina | ENSRNOP00000068606 | ENSRNOP00000056356 | Cysteine and histidine-rich protein 1. | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | 0.568 |
Cyth1 | Dnpep | ENSRNOP00000004196 | ENSRNOP00000026799 | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | Aspartyl aminopeptidase, isoform CRA_c; Belongs to the peptidase M18 family. | 0.463 |
Cyth1 | Grina | ENSRNOP00000004196 | ENSRNOP00000056356 | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | 0.478 |
Cyth1 | Nme7 | ENSRNOP00000004196 | ENSRNOP00000055684 | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.463 |
Dnpep | Cyth1 | ENSRNOP00000026799 | ENSRNOP00000004196 | Aspartyl aminopeptidase, isoform CRA_c; Belongs to the peptidase M18 family. | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | 0.463 |
Dnpep | Grina | ENSRNOP00000026799 | ENSRNOP00000056356 | Aspartyl aminopeptidase, isoform CRA_c; Belongs to the peptidase M18 family. | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | 0.509 |
Dnpep | Nme7 | ENSRNOP00000026799 | ENSRNOP00000055684 | Aspartyl aminopeptidase, isoform CRA_c; Belongs to the peptidase M18 family. | Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.491 |
Ghitm | Grina | ENSRNOP00000018723 | ENSRNOP00000056356 | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c (By similarity); Belongs to the BI1 family. | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | 0.566 |
Ghitm | Tmbim6 | ENSRNOP00000018723 | ENSRNOP00000069944 | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c (By similarity); Belongs to the BI1 family. | Bax inhibitor 1; Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation; Belongs to the BI1 family. | 0.654 |
Grin2d | Grina | ENSRNOP00000075255 | ENSRNOP00000056356 | Glutamate receptor ionotropic, NMDA 2D; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition ; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | 0.617 |
Grina | Atp6v0c | ENSRNOP00000056356 | ENSRNOP00000008736 | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). | 0.466 |
Grina | Cyhr1 | ENSRNOP00000056356 | ENSRNOP00000068606 | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | Cysteine and histidine-rich protein 1. | 0.568 |
Grina | Cyth1 | ENSRNOP00000056356 | ENSRNOP00000004196 | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | 0.478 |
Grina | Dnpep | ENSRNOP00000056356 | ENSRNOP00000026799 | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | Aspartyl aminopeptidase, isoform CRA_c; Belongs to the peptidase M18 family. | 0.509 |
Grina | Ghitm | ENSRNOP00000056356 | ENSRNOP00000018723 | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c (By similarity); Belongs to the BI1 family. | 0.566 |
Grina | Grin2d | ENSRNOP00000056356 | ENSRNOP00000075255 | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | Glutamate receptor ionotropic, NMDA 2D; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition ; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. | 0.617 |
Grina | Nme7 | ENSRNOP00000056356 | ENSRNOP00000055684 | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.472 |
Grina | Pithd1 | ENSRNOP00000056356 | ENSRNOP00000014458 | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | PITH domain-containing 1. | 0.472 |
Grina | Tmbim6 | ENSRNOP00000056356 | ENSRNOP00000069944 | Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily. | Bax inhibitor 1; Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation; Belongs to the BI1 family. | 0.612 |