STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TbcelTubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability. (424 aa)    
Predicted Functional Partners:
Tiprl
TIP41-like protein; May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma- H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and rep [...]
   
  
 0.779
Tecta
Tectorin alpha.
 
    
 0.706
Zc3h7b
Zinc finger CCCH-type-containing 7B.
   
  
 0.644
Rhpn2
Rhophilin, Rho GTPase binding protein 2 (Predicted).
   
  
 0.635
Rab11fip4
RAB11 family-interacting protein 4.
   
  
 0.583
Prrc2b
Proline-rich coiled-coil 2B.
   
  
 0.579
Polr3d
Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa.
      
 0.562
Iqub
IQ and ubiquitin-like domain-containing protein; May play roles in cilia formation and/or maintenance.
      
 0.535
Tbcd
Tubulin folding cofactor D.
      
 0.531
Tbcc
Tubulin-specific chaperone c (Predicted).
      
 0.531
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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