node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Chm | Rab2b | ENSRNOP00000000174 | ENSRNOP00000057211 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | RAB2B, member RAS oncogene family. | 0.591 |
Chm | Rabggta | ENSRNOP00000000174 | ENSRNOP00000049261 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. | 0.996 |
Chm | Rabggtb | ENSRNOP00000000174 | ENSRNOP00000061541 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Belongs to the protein prenyltransferase subunit beta family. | 0.992 |
Fam71e1 | Rab2b | ENSRNOP00000045841 | ENSRNOP00000057211 | Family with sequence similarity 71, member E1. | RAB2B, member RAS oncogene family. | 0.592 |
Fam71f2 | Rab2b | ENSRNOP00000057100 | ENSRNOP00000057211 | Protein FAM71F2; Belongs to the FAM71 family. | RAB2B, member RAS oncogene family. | 0.803 |
Itsn1 | Itsn2 | ENSRNOP00000044773 | ENSRNOP00000065329 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | Intersectin 2. | 0.618 |
Itsn1 | Rab2b | ENSRNOP00000044773 | ENSRNOP00000057211 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | RAB2B, member RAS oncogene family. | 0.590 |
Itsn2 | Itsn1 | ENSRNOP00000065329 | ENSRNOP00000044773 | Intersectin 2. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | 0.618 |
Itsn2 | Rab2b | ENSRNOP00000065329 | ENSRNOP00000057211 | Intersectin 2. | RAB2B, member RAS oncogene family. | 0.667 |
Ocel1 | Rab2b | ENSRNOP00000069818 | ENSRNOP00000057211 | Occludin/ELL domain-containing 1. | RAB2B, member RAS oncogene family. | 0.562 |
Rab2b | Chm | ENSRNOP00000057211 | ENSRNOP00000000174 | RAB2B, member RAS oncogene family. | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | 0.591 |
Rab2b | Fam71e1 | ENSRNOP00000057211 | ENSRNOP00000045841 | RAB2B, member RAS oncogene family. | Family with sequence similarity 71, member E1. | 0.592 |
Rab2b | Fam71f2 | ENSRNOP00000057211 | ENSRNOP00000057100 | RAB2B, member RAS oncogene family. | Protein FAM71F2; Belongs to the FAM71 family. | 0.803 |
Rab2b | Itsn1 | ENSRNOP00000057211 | ENSRNOP00000044773 | RAB2B, member RAS oncogene family. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles. Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | 0.590 |
Rab2b | Itsn2 | ENSRNOP00000057211 | ENSRNOP00000065329 | RAB2B, member RAS oncogene family. | Intersectin 2. | 0.667 |
Rab2b | Ocel1 | ENSRNOP00000057211 | ENSRNOP00000069818 | RAB2B, member RAS oncogene family. | Occludin/ELL domain-containing 1. | 0.562 |
Rab2b | Rab5al1 | ENSRNOP00000057211 | ENSRNOP00000070031 | RAB2B, member RAS oncogene family. | Rab5a protein. | 0.735 |
Rab2b | Rabggta | ENSRNOP00000057211 | ENSRNOP00000049261 | RAB2B, member RAS oncogene family. | Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. | 0.537 |
Rab2b | Rabggtb | ENSRNOP00000057211 | ENSRNOP00000061541 | RAB2B, member RAS oncogene family. | Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Belongs to the protein prenyltransferase subunit beta family. | 0.612 |
Rab2b | Ykt6 | ENSRNOP00000057211 | ENSRNOP00000020693 | RAB2B, member RAS oncogene family. | Synaptobrevin homolog YKT6; Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity; Belongs to the synaptobrevin family. | 0.545 |