node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccm2 | Map2k3 | ENSRNOP00000071971 | ENSRNOP00000008679 | CCM2 scaffold protein. | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | 0.661 |
Ccm2 | Map3k2 | ENSRNOP00000071971 | ENSRNOP00000057715 | CCM2 scaffold protein. | Mitogen-activated protein kinase kinase kinase 2. | 0.774 |
Ccm2 | Map3k3 | ENSRNOP00000071971 | ENSRNOP00000074780 | CCM2 scaffold protein. | Mitogen activated protein kinase kinase kinase 3 (Predicted). | 0.960 |
Lyn | Map3k2 | ENSRNOP00000011130 | ENSRNOP00000057715 | Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-c [...] | Mitogen-activated protein kinase kinase kinase 2. | 0.736 |
Lyn | Src | ENSRNOP00000011130 | ENSRNOP00000071837 | Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-c [...] | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.791 |
Map2k3 | Ccm2 | ENSRNOP00000008679 | ENSRNOP00000071971 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | CCM2 scaffold protein. | 0.661 |
Map2k3 | Map2k6 | ENSRNOP00000008679 | ENSRNOP00000006217 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | 0.953 |
Map2k3 | Map3k1 | ENSRNOP00000008679 | ENSRNOP00000017968 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. | 0.925 |
Map2k3 | Map3k2 | ENSRNOP00000008679 | ENSRNOP00000057715 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase kinase 2. | 0.925 |
Map2k3 | Map3k3 | ENSRNOP00000008679 | ENSRNOP00000074780 | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | Mitogen activated protein kinase kinase kinase 3 (Predicted). | 0.942 |
Map2k5 | Map3k1 | ENSRNOP00000050528 | ENSRNOP00000017968 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. | 0.626 |
Map2k5 | Map3k2 | ENSRNOP00000050528 | ENSRNOP00000057715 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Mitogen-activated protein kinase kinase kinase 2. | 0.988 |
Map2k5 | Map3k3 | ENSRNOP00000050528 | ENSRNOP00000074780 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | Mitogen activated protein kinase kinase kinase 3 (Predicted). | 0.993 |
Map2k6 | Map2k3 | ENSRNOP00000006217 | ENSRNOP00000008679 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | 0.953 |
Map2k6 | Map3k1 | ENSRNOP00000006217 | ENSRNOP00000017968 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. | 0.919 |
Map2k6 | Map3k2 | ENSRNOP00000006217 | ENSRNOP00000057715 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase kinase 2. | 0.921 |
Map2k6 | Map3k3 | ENSRNOP00000006217 | ENSRNOP00000074780 | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | Mitogen activated protein kinase kinase kinase 3 (Predicted). | 0.928 |
Map3k1 | Map2k3 | ENSRNOP00000017968 | ENSRNOP00000008679 | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. | Mitogen activated protein kinase kinase 3, isoform CRA_b; Belongs to the protein kinase superfamily. | 0.925 |
Map3k1 | Map2k5 | ENSRNOP00000017968 | ENSRNOP00000050528 | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). | 0.626 |
Map3k1 | Map2k6 | ENSRNOP00000017968 | ENSRNOP00000006217 | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase (By similarity). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. | Mitogen-activated protein kinase kinase 6, isoform CRA_a; Belongs to the protein kinase superfamily. | 0.919 |