node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdc42bpg | Mmp27 | ENSRNOP00000029466 | ENSRNOP00000058603 | CDC42 binding protein kinase gamma (DMPK-like) (Predicted); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Matrix metalloproteinase 27 (Predicted). | 0.408 |
Col6a6 | Mmp27 | ENSRNOP00000053252 | ENSRNOP00000058603 | Collagen type VI alpha 6 chain. | Matrix metalloproteinase 27 (Predicted). | 0.500 |
Hpx | Lim2 | ENSRNOP00000024710 | ENSRNOP00000023858 | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | 0.467 |
Hpx | Mip | ENSRNOP00000024710 | ENSRNOP00000004223 | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). | 0.425 |
Hpx | Mmp27 | ENSRNOP00000024710 | ENSRNOP00000058603 | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | Matrix metalloproteinase 27 (Predicted). | 0.445 |
Hpx | Timp1 | ENSRNOP00000024710 | ENSRNOP00000013745 | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian [...] | 0.775 |
Hpx | Timp2 | ENSRNOP00000024710 | ENSRNOP00000004290 | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. | 0.844 |
Hpx | Timp3 | ENSRNOP00000024710 | ENSRNOP00000005746 | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. | 0.625 |
Hpx | Timp4 | ENSRNOP00000024710 | ENSRNOP00000010748 | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. | 0.678 |
Kank3 | Mmp27 | ENSRNOP00000009532 | ENSRNOP00000058603 | KN motif and ankyrin repeat domains 3. | Matrix metalloproteinase 27 (Predicted). | 0.455 |
Lim2 | Hpx | ENSRNOP00000023858 | ENSRNOP00000024710 | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | 0.467 |
Lim2 | Mip | ENSRNOP00000023858 | ENSRNOP00000004223 | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). | 0.789 |
Lim2 | Mmp27 | ENSRNOP00000023858 | ENSRNOP00000058603 | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | Matrix metalloproteinase 27 (Predicted). | 0.570 |
Mip | Hpx | ENSRNOP00000004223 | ENSRNOP00000024710 | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | 0.425 |
Mip | Lim2 | ENSRNOP00000004223 | ENSRNOP00000023858 | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). | Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. | 0.789 |
Mip | Mmp27 | ENSRNOP00000004223 | ENSRNOP00000058603 | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). | Matrix metalloproteinase 27 (Predicted). | 0.548 |
Mip | Timp1 | ENSRNOP00000004223 | ENSRNOP00000013745 | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian [...] | 0.473 |
Mmp27 | Cdc42bpg | ENSRNOP00000058603 | ENSRNOP00000029466 | Matrix metalloproteinase 27 (Predicted). | CDC42 binding protein kinase gamma (DMPK-like) (Predicted); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.408 |
Mmp27 | Col6a6 | ENSRNOP00000058603 | ENSRNOP00000053252 | Matrix metalloproteinase 27 (Predicted). | Collagen type VI alpha 6 chain. | 0.500 |
Mmp27 | Hpx | ENSRNOP00000058603 | ENSRNOP00000024710 | Matrix metalloproteinase 27 (Predicted). | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | 0.445 |