node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Chd3 | Chd4 | ENSRNOP00000053890 | ENSRNOP00000052823 | Chromodomain helicase DNA-binding protein 3. | Chromodomain helicase DNA-binding protein 4. | 0.993 |
Chd3 | Gatad2a | ENSRNOP00000053890 | ENSRNOP00000027943 | Chromodomain helicase DNA-binding protein 3. | GATA zinc finger domain-containing 2A. | 0.995 |
Chd3 | Gatad2b | ENSRNOP00000053890 | ENSRNOP00000071152 | Chromodomain helicase DNA-binding protein 3. | GATA zinc finger domain-containing 2B. | 0.980 |
Chd3 | Hdac1 | ENSRNOP00000053890 | ENSRNOP00000012854 | Chromodomain helicase DNA-binding protein 3. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.998 |
Chd3 | Hdac2 | ENSRNOP00000053890 | ENSRNOP00000000742 | Chromodomain helicase DNA-binding protein 3. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.998 |
Chd3 | Mbd3 | ENSRNOP00000053890 | ENSRNOP00000041242 | Chromodomain helicase DNA-binding protein 3. | Methyl-CpG binding domain protein 3 (Predicted), isoform CRA_c. | 0.892 |
Chd3 | Mta1 | ENSRNOP00000053890 | ENSRNOP00000006521 | Chromodomain helicase DNA-binding protein 3. | Metastasis-associated protein MTA1; Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone- deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 [...] | 0.966 |
Chd3 | Mta3 | ENSRNOP00000053890 | ENSRNOP00000068747 | Chromodomain helicase DNA-binding protein 3. | Metastasis-associated 1 family, member 3. | 0.932 |
Chd3 | Rbbp4 | ENSRNOP00000053890 | ENSRNOP00000036568 | Chromodomain helicase DNA-binding protein 3. | RB-binding protein 4, chromatin-remodeling factor. | 0.995 |
Chd3 | Rbbp7 | ENSRNOP00000053890 | ENSRNOP00000062148 | Chromodomain helicase DNA-binding protein 3. | Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and [...] | 0.991 |
Chd4 | Chd3 | ENSRNOP00000052823 | ENSRNOP00000053890 | Chromodomain helicase DNA-binding protein 4. | Chromodomain helicase DNA-binding protein 3. | 0.993 |
Chd4 | Gatad2a | ENSRNOP00000052823 | ENSRNOP00000027943 | Chromodomain helicase DNA-binding protein 4. | GATA zinc finger domain-containing 2A. | 0.993 |
Chd4 | Gatad2b | ENSRNOP00000052823 | ENSRNOP00000071152 | Chromodomain helicase DNA-binding protein 4. | GATA zinc finger domain-containing 2B. | 0.988 |
Chd4 | Hdac1 | ENSRNOP00000052823 | ENSRNOP00000012854 | Chromodomain helicase DNA-binding protein 4. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.999 |
Chd4 | Hdac2 | ENSRNOP00000052823 | ENSRNOP00000000742 | Chromodomain helicase DNA-binding protein 4. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.999 |
Chd4 | Mbd3 | ENSRNOP00000052823 | ENSRNOP00000041242 | Chromodomain helicase DNA-binding protein 4. | Methyl-CpG binding domain protein 3 (Predicted), isoform CRA_c. | 0.973 |
Chd4 | Mta1 | ENSRNOP00000052823 | ENSRNOP00000006521 | Chromodomain helicase DNA-binding protein 4. | Metastasis-associated protein MTA1; Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone- deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 [...] | 0.986 |
Chd4 | Mta3 | ENSRNOP00000052823 | ENSRNOP00000068747 | Chromodomain helicase DNA-binding protein 4. | Metastasis-associated 1 family, member 3. | 0.957 |
Chd4 | Rbbp4 | ENSRNOP00000052823 | ENSRNOP00000036568 | Chromodomain helicase DNA-binding protein 4. | RB-binding protein 4, chromatin-remodeling factor. | 0.988 |
Chd4 | Rbbp7 | ENSRNOP00000052823 | ENSRNOP00000062148 | Chromodomain helicase DNA-binding protein 4. | Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and [...] | 0.991 |