STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rfx5Regulatory factor X, 5 (Influences HLA class II expression) (Predicted). (681 aa)    
Predicted Functional Partners:
Rfxank
Regulatory factor X-associated ankyrin-containing protein.
   
 0.999
Rfxapl1
Regulatory factor X-associated protein-like 1.
    
 0.997
Ciita
Class II, major histocompatibility complex, transactivator, isoform CRA_c.
    
 0.997
Rfxap
Regulatory factor X-associated protein.
    
 
 0.975
Rfx8
RFX family member 8, lacking RFX DNA-binding domain.
      
 0.673
Creb1
Cyclic AMP-responsive element-binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Belongs to the bZIP family.
   
 
 0.662
Cryzl1
Crystallin, zeta (Quinone reductase)-like 1.
      
 0.604
Urb1
URB1 ribosome biogenesis homolog.
      
 0.603
Nfyb
Nuclear transcription factor Y subunit beta; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
      
 0.598
Atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 
 0.593
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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