node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
E2f6 | Hcfc1 | ENSRNOP00000057241 | ENSRNOP00000073793 | E2F transcription factor 6. | Host cell factor C1. | 0.779 |
E2f6 | Kmt2a | ENSRNOP00000057241 | ENSRNOP00000020573 | E2F transcription factor 6. | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | 0.739 |
E2f6 | Kmt2b | ENSRNOP00000057241 | ENSRNOP00000071806 | E2F transcription factor 6. | Lysine methyltransferase 2B. | 0.733 |
E2f6 | L3mbtl2 | ENSRNOP00000057241 | ENSRNOP00000031908 | E2F transcription factor 6. | Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). | 0.984 |
E2f6 | Max | ENSRNOP00000057241 | ENSRNOP00000072268 | E2F transcription factor 6. | Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements (By similarity). | 0.918 |
E2f6 | Mga | ENSRNOP00000057241 | ENSRNOP00000060519 | E2F transcription factor 6. | MAX dimerization protein MGA. | 0.917 |
E2f6 | Pcgf6 | ENSRNOP00000057241 | ENSRNOP00000027450 | E2F transcription factor 6. | Polycomb group RING finger protein 6; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 [...] | 0.988 |
E2f6 | Rnf2 | ENSRNOP00000057241 | ENSRNOP00000068794 | E2F transcription factor 6. | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] | 0.969 |
E2f6 | Wdr5 | ENSRNOP00000057241 | ENSRNOP00000011556 | E2F transcription factor 6. | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] | 0.903 |
E2f6 | Yaf2 | ENSRNOP00000057241 | ENSRNOP00000006621 | E2F transcription factor 6. | YY1-associated factor 2. | 0.907 |
Hcfc1 | E2f6 | ENSRNOP00000073793 | ENSRNOP00000057241 | Host cell factor C1. | E2F transcription factor 6. | 0.779 |
Hcfc1 | Kmt2a | ENSRNOP00000073793 | ENSRNOP00000020573 | Host cell factor C1. | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | 0.935 |
Hcfc1 | Kmt2b | ENSRNOP00000073793 | ENSRNOP00000071806 | Host cell factor C1. | Lysine methyltransferase 2B. | 0.830 |
Hcfc1 | Max | ENSRNOP00000073793 | ENSRNOP00000072268 | Host cell factor C1. | Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements (By similarity). | 0.756 |
Hcfc1 | Mga | ENSRNOP00000073793 | ENSRNOP00000060519 | Host cell factor C1. | MAX dimerization protein MGA. | 0.754 |
Hcfc1 | Rnf2 | ENSRNOP00000073793 | ENSRNOP00000068794 | Host cell factor C1. | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] | 0.748 |
Hcfc1 | Wdr5 | ENSRNOP00000073793 | ENSRNOP00000011556 | Host cell factor C1. | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] | 0.980 |
Kmt2a | E2f6 | ENSRNOP00000020573 | ENSRNOP00000057241 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | E2F transcription factor 6. | 0.739 |
Kmt2a | Hcfc1 | ENSRNOP00000020573 | ENSRNOP00000073793 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | Host cell factor C1. | 0.935 |
Kmt2a | Kmt2b | ENSRNOP00000020573 | ENSRNOP00000071806 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. | Lysine methyltransferase 2B. | 0.887 |