node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc36 | Cxxc1 | ENSRNOP00000065793 | ENSRNOP00000020472 | Coiled-coil domain-containing 36. | CXXC finger 1 (PHD domain), isoform CRA_b. | 0.671 |
Ccdc36 | Prdm9 | ENSRNOP00000065793 | ENSRNOP00000060531 | Coiled-coil domain-containing 36. | Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] | 0.679 |
Ccdc36 | Spo11 | ENSRNOP00000065793 | ENSRNOP00000075147 | Coiled-coil domain-containing 36. | SPO11, initiator of meiotic double stranded breaks. | 0.692 |
Cdyl | Cxxc1 | ENSRNOP00000048651 | ENSRNOP00000020472 | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | CXXC finger 1 (PHD domain), isoform CRA_b. | 0.579 |
Cdyl | Ehmt2 | ENSRNOP00000048651 | ENSRNOP00000042145 | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | Euchromatic histone lysine methyltransferase 2. | 0.859 |
Cdyl | H3c1 | ENSRNOP00000048651 | ENSRNOP00000064431 | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.576 |
Cdyl | LOC684762 | ENSRNOP00000048651 | ENSRNOP00000044600 | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | Histone H3; Belongs to the histone H3 family. | 0.563 |
Cdyl | Prdm9 | ENSRNOP00000048651 | ENSRNOP00000060531 | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] | 0.687 |
Cdyl | Spo11 | ENSRNOP00000048651 | ENSRNOP00000075147 | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | SPO11, initiator of meiotic double stranded breaks. | 0.476 |
Cxxc1 | Ccdc36 | ENSRNOP00000020472 | ENSRNOP00000065793 | CXXC finger 1 (PHD domain), isoform CRA_b. | Coiled-coil domain-containing 36. | 0.671 |
Cxxc1 | Cdyl | ENSRNOP00000020472 | ENSRNOP00000048651 | CXXC finger 1 (PHD domain), isoform CRA_b. | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | 0.579 |
Cxxc1 | Ehmt2 | ENSRNOP00000020472 | ENSRNOP00000042145 | CXXC finger 1 (PHD domain), isoform CRA_b. | Euchromatic histone lysine methyltransferase 2. | 0.683 |
Cxxc1 | H3c1 | ENSRNOP00000020472 | ENSRNOP00000064431 | CXXC finger 1 (PHD domain), isoform CRA_b. | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.463 |
Cxxc1 | LOC684762 | ENSRNOP00000020472 | ENSRNOP00000044600 | CXXC finger 1 (PHD domain), isoform CRA_b. | Histone H3; Belongs to the histone H3 family. | 0.463 |
Cxxc1 | Prdm9 | ENSRNOP00000020472 | ENSRNOP00000060531 | CXXC finger 1 (PHD domain), isoform CRA_b. | Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] | 0.874 |
Cxxc1 | Spo11 | ENSRNOP00000020472 | ENSRNOP00000075147 | CXXC finger 1 (PHD domain), isoform CRA_b. | SPO11, initiator of meiotic double stranded breaks. | 0.620 |
Ehmt2 | Cdyl | ENSRNOP00000042145 | ENSRNOP00000048651 | Euchromatic histone lysine methyltransferase 2. | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | 0.859 |
Ehmt2 | Cxxc1 | ENSRNOP00000042145 | ENSRNOP00000020472 | Euchromatic histone lysine methyltransferase 2. | CXXC finger 1 (PHD domain), isoform CRA_b. | 0.683 |
Ehmt2 | H3c1 | ENSRNOP00000042145 | ENSRNOP00000064431 | Euchromatic histone lysine methyltransferase 2. | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.931 |
Ehmt2 | LOC684762 | ENSRNOP00000042145 | ENSRNOP00000044600 | Euchromatic histone lysine methyltransferase 2. | Histone H3; Belongs to the histone H3 family. | 0.932 |