node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ambra1 | Atg13 | ENSRNOP00000039742 | ENSRNOP00000022841 | Autophagy and beclin 1 regulator 1. | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | 0.910 |
Ambra1 | Atg14 | ENSRNOP00000039742 | ENSRNOP00000016274 | Autophagy and beclin 1 regulator 1. | Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans- Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1- dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t [...] | 0.999 |
Ambra1 | Becn1 | ENSRNOP00000039742 | ENSRNOP00000071966 | Autophagy and beclin 1 regulator 1. | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | 0.999 |
Ambra1 | Gabarap | ENSRNOP00000039742 | ENSRNOP00000023724 | Autophagy and beclin 1 regulator 1. | Gamma-aminobutyric acid receptor-associated protein; Involved in apoptosis (By similarity). May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy (By similarity). | 0.725 |
Ambra1 | Nrbf2 | ENSRNOP00000039742 | ENSRNOP00000000794 | Autophagy and beclin 1 regulator 1. | Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Belongs to the NRBF family. | 0.985 |
Ambra1 | Pik3c3 | ENSRNOP00000039742 | ENSRNOP00000060791 | Autophagy and beclin 1 regulator 1. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to [...] | 0.999 |
Ambra1 | Pik3r4 | ENSRNOP00000039742 | ENSRNOP00000018654 | Autophagy and beclin 1 regulator 1. | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.998 |
Ambra1 | Rb1cc1 | ENSRNOP00000039742 | ENSRNOP00000060201 | Autophagy and beclin 1 regulator 1. | RB1-inducible coiled-coil 1 (Predicted). | 0.858 |
Ambra1 | Ulk2 | ENSRNOP00000039742 | ENSRNOP00000003792 | Autophagy and beclin 1 regulator 1. | Unc-51-like autophagy-activating kinase 2. | 0.975 |
Ambra1 | Uvrag | ENSRNOP00000039742 | ENSRNOP00000022176 | Autophagy and beclin 1 regulator 1. | Similar to UV radiation resistance associated, isoform CRA_d. | 0.996 |
Atg13 | Ambra1 | ENSRNOP00000022841 | ENSRNOP00000039742 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | Autophagy and beclin 1 regulator 1. | 0.910 |
Atg13 | Atg14 | ENSRNOP00000022841 | ENSRNOP00000016274 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans- Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1- dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t [...] | 0.994 |
Atg13 | Becn1 | ENSRNOP00000022841 | ENSRNOP00000071966 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | 0.983 |
Atg13 | Gabarap | ENSRNOP00000022841 | ENSRNOP00000023724 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | Gamma-aminobutyric acid receptor-associated protein; Involved in apoptosis (By similarity). May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy (By similarity). | 0.898 |
Atg13 | Nrbf2 | ENSRNOP00000022841 | ENSRNOP00000000794 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Belongs to the NRBF family. | 0.873 |
Atg13 | Pik3c3 | ENSRNOP00000022841 | ENSRNOP00000060791 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to [...] | 0.987 |
Atg13 | Pik3r4 | ENSRNOP00000022841 | ENSRNOP00000018654 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.941 |
Atg13 | Rb1cc1 | ENSRNOP00000022841 | ENSRNOP00000060201 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | RB1-inducible coiled-coil 1 (Predicted). | 0.999 |
Atg13 | Ulk2 | ENSRNOP00000022841 | ENSRNOP00000003792 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | Unc-51-like autophagy-activating kinase 2. | 0.999 |
Atg13 | Uvrag | ENSRNOP00000022841 | ENSRNOP00000022176 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. | Similar to UV radiation resistance associated, isoform CRA_d. | 0.854 |