node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cul1 | Cul2 | ENSRNOP00000007620 | ENSRNOP00000074075 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Cullin 2; Belongs to the cullin family. | 0.612 |
Cul1 | Cul3 | ENSRNOP00000007620 | ENSRNOP00000021528 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the [...] | 0.793 |
Cul1 | Cul5 | ENSRNOP00000007620 | ENSRNOP00000010956 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] | 0.808 |
Cul1 | Nae1 | ENSRNOP00000007620 | ENSRNOP00000045593 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. | 0.856 |
Cul1 | Nedd8 | ENSRNOP00000007620 | ENSRNOP00000061284 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.998 |
Cul1 | Rbx1 | ENSRNOP00000007620 | ENSRNOP00000069049 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Ring-box 1. | 0.999 |
Cul1 | Senp8 | ENSRNOP00000007620 | ENSRNOP00000062239 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Sentrin-specific protease 8; Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. | 0.614 |
Cul1 | Uba3 | ENSRNOP00000007620 | ENSRNOP00000008893 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression. | 0.873 |
Cul1 | Ube2f | ENSRNOP00000007620 | ENSRNOP00000027050 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. | 0.865 |
Cul1 | Ube2m | ENSRNOP00000007620 | ENSRNOP00000034271 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. | 0.973 |
Cul2 | Cul1 | ENSRNOP00000074075 | ENSRNOP00000007620 | Cullin 2; Belongs to the cullin family. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.612 |
Cul2 | Cul3 | ENSRNOP00000074075 | ENSRNOP00000021528 | Cullin 2; Belongs to the cullin family. | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the [...] | 0.808 |
Cul2 | Cul5 | ENSRNOP00000074075 | ENSRNOP00000010956 | Cullin 2; Belongs to the cullin family. | Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] | 0.801 |
Cul2 | Nae1 | ENSRNOP00000074075 | ENSRNOP00000045593 | Cullin 2; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. | 0.769 |
Cul2 | Nedd8 | ENSRNOP00000074075 | ENSRNOP00000061284 | Cullin 2; Belongs to the cullin family. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.980 |
Cul2 | Rbx1 | ENSRNOP00000074075 | ENSRNOP00000069049 | Cullin 2; Belongs to the cullin family. | Ring-box 1. | 0.999 |
Cul2 | Senp8 | ENSRNOP00000074075 | ENSRNOP00000062239 | Cullin 2; Belongs to the cullin family. | Sentrin-specific protease 8; Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. | 0.407 |
Cul2 | Uba3 | ENSRNOP00000074075 | ENSRNOP00000008893 | Cullin 2; Belongs to the cullin family. | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression. | 0.843 |
Cul2 | Ube2f | ENSRNOP00000074075 | ENSRNOP00000027050 | Cullin 2; Belongs to the cullin family. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. | 0.449 |
Cul2 | Ube2m | ENSRNOP00000074075 | ENSRNOP00000034271 | Cullin 2; Belongs to the cullin family. | Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. | 0.781 |