node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Esyt1 | Osbp | ENSRNOP00000070299 | ENSRNOP00000061365 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.702 |
Esyt1 | Pitpnm1 | ENSRNOP00000070299 | ENSRNOP00000025084 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium [...] | 0.685 |
Esyt1 | Sacm1l | ENSRNOP00000070299 | ENSRNOP00000007223 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2. | 0.525 |
Esyt1 | Vapa | ENSRNOP00000070299 | ENSRNOP00000074577 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (By similarity). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (By similarity). With OSBPL3, may regulate ER morphology (By similarity). May play a role in vesicle trafficking. | 0.529 |
Esyt1 | Vapb | ENSRNOP00000070299 | ENSRNOP00000007554 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. | 0.489 |
LOC686087 | Osbp | ENSRNOP00000073210 | ENSRNOP00000061365 | Similar to motile sperm domain containing 1. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.711 |
LOC686087 | Stard3 | ENSRNOP00000073210 | ENSRNOP00000059898 | Similar to motile sperm domain containing 1. | StAR-related lipid transfer (START) domain containing 3. | 0.638 |
LOC686087 | Vapa | ENSRNOP00000073210 | ENSRNOP00000074577 | Similar to motile sperm domain containing 1. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (By similarity). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (By similarity). With OSBPL3, may regulate ER morphology (By similarity). May play a role in vesicle trafficking. | 0.623 |
LOC686087 | Vapb | ENSRNOP00000073210 | ENSRNOP00000007554 | Similar to motile sperm domain containing 1. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. | 0.411 |
Mospd1 | Osbp | ENSRNOP00000003192 | ENSRNOP00000061365 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.711 |
Mospd1 | Stard3 | ENSRNOP00000003192 | ENSRNOP00000059898 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | StAR-related lipid transfer (START) domain containing 3. | 0.638 |
Mospd1 | Vapa | ENSRNOP00000003192 | ENSRNOP00000074577 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (By similarity). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (By similarity). With OSBPL3, may regulate ER morphology (By similarity). May play a role in vesicle trafficking. | 0.630 |
Mospd1 | Vapb | ENSRNOP00000003192 | ENSRNOP00000007554 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. | 0.411 |
Mospd4 | Osbp | ENSRNOP00000004747 | ENSRNOP00000061365 | Motile sperm domain-containing 4. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.887 |
Mospd4 | Pitpnm1 | ENSRNOP00000004747 | ENSRNOP00000025084 | Motile sperm domain-containing 4. | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium [...] | 0.448 |
Mospd4 | Stard3 | ENSRNOP00000004747 | ENSRNOP00000059898 | Motile sperm domain-containing 4. | StAR-related lipid transfer (START) domain containing 3. | 0.850 |
Mospd4 | Vapb | ENSRNOP00000004747 | ENSRNOP00000007554 | Motile sperm domain-containing 4. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. | 0.616 |
Osbp | Esyt1 | ENSRNOP00000061365 | ENSRNOP00000070299 | Oxysterol-binding protein; Belongs to the OSBP family. | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity). Belongs to the extended synaptotagmin family. | 0.702 |
Osbp | LOC686087 | ENSRNOP00000061365 | ENSRNOP00000073210 | Oxysterol-binding protein; Belongs to the OSBP family. | Similar to motile sperm domain containing 1. | 0.711 |
Osbp | Mospd1 | ENSRNOP00000061365 | ENSRNOP00000003192 | Oxysterol-binding protein; Belongs to the OSBP family. | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | 0.711 |