node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dhps | Eif5a | ENSRNOP00000005656 | ENSRNOP00000022343 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. | Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). Ma [...] | 0.992 |
Dhps | Peak1 | ENSRNOP00000005656 | ENSRNOP00000061695 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. | Similar to RIKEN cDNA C230081A13 (Predicted). | 0.526 |
Eif5a | Dhps | ENSRNOP00000022343 | ENSRNOP00000005656 | Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). Ma [...] | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. | 0.992 |
Eif5a | Peak1 | ENSRNOP00000022343 | ENSRNOP00000061695 | Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). Ma [...] | Similar to RIKEN cDNA C230081A13 (Predicted). | 0.628 |
Epha2 | Git2 | ENSRNOP00000012328 | ENSRNOP00000048331 | Eph receptor A2 (Predicted). | G protein-coupled receptor kinase interacting ArfGAP 2. | 0.441 |
Epha2 | Peak1 | ENSRNOP00000012328 | ENSRNOP00000061695 | Eph receptor A2 (Predicted). | Similar to RIKEN cDNA C230081A13 (Predicted). | 0.495 |
Epha2 | Rhou | ENSRNOP00000012328 | ENSRNOP00000069781 | Eph receptor A2 (Predicted). | Ras homolog family member U. | 0.568 |
Epha2 | Rhov | ENSRNOP00000012328 | ENSRNOP00000018277 | Eph receptor A2 (Predicted). | Rho-related GTP-binding protein RhoV; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway; Belongs to the small GTPase superfamily. Rho family. | 0.575 |
Epha2 | Sptbn1 | ENSRNOP00000012328 | ENSRNOP00000074766 | Eph receptor A2 (Predicted). | Spectrin beta chain; Belongs to the spectrin family. | 0.413 |
Fam20a | Pan3 | ENSRNOP00000005367 | ENSRNOP00000040388 | FAM20A, golgi-associated secretory pathway pseudokinase. | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | 0.546 |
Fam20a | Peak1 | ENSRNOP00000005367 | ENSRNOP00000061695 | FAM20A, golgi-associated secretory pathway pseudokinase. | Similar to RIKEN cDNA C230081A13 (Predicted). | 0.679 |
Fam20a | Stkld1 | ENSRNOP00000005367 | ENSRNOP00000029627 | FAM20A, golgi-associated secretory pathway pseudokinase. | Serine/threonine kinase-like domain-containing 1. | 0.655 |
Git2 | Epha2 | ENSRNOP00000048331 | ENSRNOP00000012328 | G protein-coupled receptor kinase interacting ArfGAP 2. | Eph receptor A2 (Predicted). | 0.441 |
Git2 | Peak1 | ENSRNOP00000048331 | ENSRNOP00000061695 | G protein-coupled receptor kinase interacting ArfGAP 2. | Similar to RIKEN cDNA C230081A13 (Predicted). | 0.485 |
Git2 | Rhou | ENSRNOP00000048331 | ENSRNOP00000069781 | G protein-coupled receptor kinase interacting ArfGAP 2. | Ras homolog family member U. | 0.538 |
Git2 | Rhov | ENSRNOP00000048331 | ENSRNOP00000018277 | G protein-coupled receptor kinase interacting ArfGAP 2. | Rho-related GTP-binding protein RhoV; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway; Belongs to the small GTPase superfamily. Rho family. | 0.538 |
Git2 | Sptbn1 | ENSRNOP00000048331 | ENSRNOP00000074766 | G protein-coupled receptor kinase interacting ArfGAP 2. | Spectrin beta chain; Belongs to the spectrin family. | 0.461 |
Pan3 | Fam20a | ENSRNOP00000040388 | ENSRNOP00000005367 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | FAM20A, golgi-associated secretory pathway pseudokinase. | 0.546 |
Pan3 | Peak1 | ENSRNOP00000040388 | ENSRNOP00000061695 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | Similar to RIKEN cDNA C230081A13 (Predicted). | 0.538 |
Pan3 | Stkld1 | ENSRNOP00000040388 | ENSRNOP00000029627 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | Serine/threonine kinase-like domain-containing 1. | 0.769 |