STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ankrd42Ankyrin repeat domain 42 (Predicted), isoform CRA_a. (521 aa)    
Predicted Functional Partners:
Zcchc14
Zinc finger CCHC-type-containing 14.
    
 
 0.680
Ppp1r8
Protein phosphatase 1, regulatory (Inhibitor) subunit 8 (Predicted).
   
  
 0.644
Ripor3
RIPOR family member 3.
   
 
 0.640
Sgtb
Small glutamine-rich tetratricopeptide repeat-containing protein beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
   
 
 0.638
Iqub
IQ and ubiquitin-like domain-containing protein; May play roles in cilia formation and/or maintenance.
   
 
 0.609
Apobr
Apolipoprotein B receptor.
      
 0.602
Trim23
E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.
   
 
 0.597
Dnaaf1
Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity); Belongs to the DNAAF1 family.
   
   0.593
Zbbx
Zinc finger, B-box domain-containing.
   
    0.592
Pacrgl
Similar to RIKEN cDNA 4933428G09 (Predicted), isoform CRA_b.
   
 
 0.562
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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