Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Akt1s1 | Deptor | ENSRNOP00000027478 | ENSRNOP00000005722 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | DEP domain-containing MTOR-interacting protein. | 0.999 |
| Akt1s1 | Eif4ebp1 | ENSRNOP00000027478 | ENSRNOP00000016885 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Eukaryotic translation initiation factor 4E-binding protein 1; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase a [...] | 0.966 |
| Akt1s1 | Mlst8 | ENSRNOP00000027478 | ENSRNOP00000014269 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.999 |
| Akt1s1 | Mtor | ENSRNOP00000027478 | ENSRNOP00000014167 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.999 |
| Akt1s1 | Rheb | ENSRNOP00000027478 | ENSRNOP00000063915 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. | 0.994 |
| Akt1s1 | Rptor | ENSRNOP00000027478 | ENSRNOP00000005337 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Regulatory-associated protein of MTOR, complex 1. | 0.999 |
| Akt1s1 | Tbc1d7 | ENSRNOP00000027478 | ENSRNOP00000019089 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | TBC1 domain family, member 7. | 0.630 |
| Akt1s1 | Tsc1 | ENSRNOP00000027478 | ENSRNOP00000016904 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Hamartin; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (By similarity). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (By similarity). Competes wit [...] | 0.704 |
| Akt1s1 | Tsc2 | ENSRNOP00000027478 | ENSRNOP00000016221 | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | Tuberin; In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. | 0.856 |
| Bnip3 | Mtor | ENSRNOP00000023477 | ENSRNOP00000014167 | BCL2/adenovirus E1B 19 kDa-interacting protein 3. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.634 |
| Bnip3 | Rheb | ENSRNOP00000023477 | ENSRNOP00000063915 | BCL2/adenovirus E1B 19 kDa-interacting protein 3. | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. | 0.993 |
| Bnip3 | Tsc2 | ENSRNOP00000023477 | ENSRNOP00000016221 | BCL2/adenovirus E1B 19 kDa-interacting protein 3. | Tuberin; In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. | 0.524 |
| Deptor | Akt1s1 | ENSRNOP00000005722 | ENSRNOP00000027478 | DEP domain-containing MTOR-interacting protein. | AKT1 substrate 1 (Proline-rich) (Predicted), isoform CRA_d. | 0.999 |
| Deptor | Eif4ebp1 | ENSRNOP00000005722 | ENSRNOP00000016885 | DEP domain-containing MTOR-interacting protein. | Eukaryotic translation initiation factor 4E-binding protein 1; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase a [...] | 0.550 |
| Deptor | Mlst8 | ENSRNOP00000005722 | ENSRNOP00000014269 | DEP domain-containing MTOR-interacting protein. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.999 |
| Deptor | Mtor | ENSRNOP00000005722 | ENSRNOP00000014167 | DEP domain-containing MTOR-interacting protein. | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome [...] | 0.999 |
| Deptor | Rheb | ENSRNOP00000005722 | ENSRNOP00000063915 | DEP domain-containing MTOR-interacting protein. | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. | 0.987 |
| Deptor | Rptor | ENSRNOP00000005722 | ENSRNOP00000005337 | DEP domain-containing MTOR-interacting protein. | Regulatory-associated protein of MTOR, complex 1. | 0.999 |
| Deptor | Tbc1d7 | ENSRNOP00000005722 | ENSRNOP00000019089 | DEP domain-containing MTOR-interacting protein. | TBC1 domain family, member 7. | 0.563 |
| Deptor | Tsc1 | ENSRNOP00000005722 | ENSRNOP00000016904 | DEP domain-containing MTOR-interacting protein. | Hamartin; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (By similarity). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (By similarity). Competes wit [...] | 0.609 |
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