node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dr1 | Drap1 | ENSRNOP00000064336 | ENSRNOP00000032674 | Down-regulator of transcription 1. | Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). Belongs to the NC2 alpha/DRAP1 family. | 0.955 |
Dr1 | Kat14 | ENSRNOP00000064336 | ENSRNOP00000009437 | Down-regulator of transcription 1. | Lysine acetyltransferase 14. | 0.920 |
Dr1 | LOC100362333 | ENSRNOP00000064336 | ENSRNOP00000006416 | Down-regulator of transcription 1. | DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). | 0.889 |
Dr1 | Mbip | ENSRNOP00000064336 | ENSRNOP00000011419 | Down-regulator of transcription 1. | MAP3K12-binding inhibitory protein 1. | 0.897 |
Dr1 | Pole3 | ENSRNOP00000064336 | ENSRNOP00000070346 | Down-regulator of transcription 1. | DNA-directed DNA polymerase epsilon 3. | 0.889 |
Dr1 | Sgf29 | ENSRNOP00000064336 | ENSRNOP00000026146 | Down-regulator of transcription 1. | SAGA-associated factor 29; Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (By similarity). May be in [...] | 0.885 |
Dr1 | Tada2a | ENSRNOP00000064336 | ENSRNOP00000003699 | Down-regulator of transcription 1. | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA [...] | 0.907 |
Dr1 | Tbp | ENSRNOP00000064336 | ENSRNOP00000002038 | Down-regulator of transcription 1. | TATA box binding protein, isoform CRA_a. | 0.878 |
Dr1 | Wdr5 | ENSRNOP00000064336 | ENSRNOP00000011556 | Down-regulator of transcription 1. | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] | 0.877 |
Dr1 | Yeats2 | ENSRNOP00000064336 | ENSRNOP00000062371 | Down-regulator of transcription 1. | Similar to YEATS domain containing 2 (Predicted). | 0.922 |
Drap1 | Dr1 | ENSRNOP00000032674 | ENSRNOP00000064336 | Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). Belongs to the NC2 alpha/DRAP1 family. | Down-regulator of transcription 1. | 0.955 |
Drap1 | Tbp | ENSRNOP00000032674 | ENSRNOP00000002038 | Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). Belongs to the NC2 alpha/DRAP1 family. | TATA box binding protein, isoform CRA_a. | 0.883 |
Kat14 | Dr1 | ENSRNOP00000009437 | ENSRNOP00000064336 | Lysine acetyltransferase 14. | Down-regulator of transcription 1. | 0.920 |
Kat14 | LOC100362333 | ENSRNOP00000009437 | ENSRNOP00000006416 | Lysine acetyltransferase 14. | DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). | 0.833 |
Kat14 | Mbip | ENSRNOP00000009437 | ENSRNOP00000011419 | Lysine acetyltransferase 14. | MAP3K12-binding inhibitory protein 1. | 0.926 |
Kat14 | Pole3 | ENSRNOP00000009437 | ENSRNOP00000070346 | Lysine acetyltransferase 14. | DNA-directed DNA polymerase epsilon 3. | 0.833 |
Kat14 | Sgf29 | ENSRNOP00000009437 | ENSRNOP00000026146 | Lysine acetyltransferase 14. | SAGA-associated factor 29; Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (By similarity). May be in [...] | 0.993 |
Kat14 | Tada2a | ENSRNOP00000009437 | ENSRNOP00000003699 | Lysine acetyltransferase 14. | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA [...] | 0.924 |
Kat14 | Wdr5 | ENSRNOP00000009437 | ENSRNOP00000011556 | Lysine acetyltransferase 14. | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] | 0.879 |
Kat14 | Yeats2 | ENSRNOP00000009437 | ENSRNOP00000062371 | Lysine acetyltransferase 14. | Similar to YEATS domain containing 2 (Predicted). | 0.978 |