node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cd19 | Cd27 | ENSRNOP00000051906 | ENSRNOP00000029803 | CD19 molecule. | Similar to CD27 antigen-mouse, isoform CRA_b. | 0.880 |
Cd19 | Cd276 | ENSRNOP00000051906 | ENSRNOP00000049249 | CD19 molecule. | CD276 antigen; Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. May play a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T- cell dependent killing of tumor cells (By similarity). | 0.669 |
Cd19 | Cd4 | ENSRNOP00000051906 | ENSRNOP00000021915 | CD19 molecule. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.979 |
Cd19 | Cd40 | ENSRNOP00000051906 | ENSRNOP00000052022 | CD19 molecule. | Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a. | 0.839 |
Cd19 | Cd40lg | ENSRNOP00000051906 | ENSRNOP00000001162 | CD19 molecule. | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | 0.769 |
Cd19 | Cd70 | ENSRNOP00000051906 | ENSRNOP00000064850 | CD19 molecule. | Cd70 molecule; Belongs to the tumor necrosis factor family. | 0.777 |
Cd19 | Icos | ENSRNOP00000051906 | ENSRNOP00000064455 | CD19 molecule. | Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...] | 0.863 |
Cd19 | Tnfrsf4 | ENSRNOP00000051906 | ENSRNOP00000027251 | CD19 molecule. | Tumor necrosis factor receptor superfamily member 4; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity). | 0.632 |
Cd19 | Tnfrsf9 | ENSRNOP00000051906 | ENSRNOP00000052371 | CD19 molecule. | Similar to T-cell antigen 4-1BB-mouse, isoform CRA_a. | 0.842 |
Cd19 | Tnfsf4 | ENSRNOP00000051906 | ENSRNOP00000003969 | CD19 molecule. | Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity); Belongs to the tumor necrosis factor family. | 0.454 |
Cd27 | Cd19 | ENSRNOP00000029803 | ENSRNOP00000051906 | Similar to CD27 antigen-mouse, isoform CRA_b. | CD19 molecule. | 0.880 |
Cd27 | Cd276 | ENSRNOP00000029803 | ENSRNOP00000049249 | Similar to CD27 antigen-mouse, isoform CRA_b. | CD276 antigen; Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. May play a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T- cell dependent killing of tumor cells (By similarity). | 0.760 |
Cd27 | Cd4 | ENSRNOP00000029803 | ENSRNOP00000021915 | Similar to CD27 antigen-mouse, isoform CRA_b. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.904 |
Cd27 | Cd40 | ENSRNOP00000029803 | ENSRNOP00000052022 | Similar to CD27 antigen-mouse, isoform CRA_b. | Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a. | 0.633 |
Cd27 | Cd40lg | ENSRNOP00000029803 | ENSRNOP00000001162 | Similar to CD27 antigen-mouse, isoform CRA_b. | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | 0.864 |
Cd27 | Cd70 | ENSRNOP00000029803 | ENSRNOP00000064850 | Similar to CD27 antigen-mouse, isoform CRA_b. | Cd70 molecule; Belongs to the tumor necrosis factor family. | 0.999 |
Cd27 | Icos | ENSRNOP00000029803 | ENSRNOP00000064455 | Similar to CD27 antigen-mouse, isoform CRA_b. | Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...] | 0.787 |
Cd27 | Tnfrsf4 | ENSRNOP00000029803 | ENSRNOP00000027251 | Similar to CD27 antigen-mouse, isoform CRA_b. | Tumor necrosis factor receptor superfamily member 4; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity). | 0.889 |
Cd27 | Tnfrsf9 | ENSRNOP00000029803 | ENSRNOP00000052371 | Similar to CD27 antigen-mouse, isoform CRA_b. | Similar to T-cell antigen 4-1BB-mouse, isoform CRA_a. | 0.884 |
Cd27 | Tnfsf4 | ENSRNOP00000029803 | ENSRNOP00000003969 | Similar to CD27 antigen-mouse, isoform CRA_b. | Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity); Belongs to the tumor necrosis factor family. | 0.952 |