node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adgrl1 | Erbin | ENSRNOP00000045873 | ENSRNOP00000066263 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. | Erbb2-interacting protein. | 0.710 |
Adgrl1 | Pkp4 | ENSRNOP00000045873 | ENSRNOP00000056013 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. | Plakophilin 4. | 0.497 |
Adgrl2 | Erbin | ENSRNOP00000042136 | ENSRNOP00000066263 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Erbb2-interacting protein. | 0.758 |
Adgrl3 | Erbin | ENSRNOP00000045365 | ENSRNOP00000066263 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Erbb2-interacting protein. | 0.710 |
Adgrl3 | Pkp4 | ENSRNOP00000045365 | ENSRNOP00000056013 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Plakophilin 4. | 0.474 |
Arvcf | Erbin | ENSRNOP00000047113 | ENSRNOP00000066263 | ARVCF, delta catenin family member. | Erbb2-interacting protein. | 0.737 |
Dsg1 | Erbin | ENSRNOP00000058060 | ENSRNOP00000066263 | Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Erbb2-interacting protein. | 0.726 |
Dsg1 | Pkp4 | ENSRNOP00000058060 | ENSRNOP00000056013 | Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Plakophilin 4. | 0.616 |
Erbb2 | Erbin | ENSRNOP00000040591 | ENSRNOP00000066263 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | Erbb2-interacting protein. | 0.994 |
Erbb2 | LOC102552659 | ENSRNOP00000040591 | ENSRNOP00000064298 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | Receptor tyrosine-protein kinase erbB-2-like. | 0.808 |
Erbin | Adgrl1 | ENSRNOP00000066263 | ENSRNOP00000045873 | Erbb2-interacting protein. | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. | 0.710 |
Erbin | Adgrl2 | ENSRNOP00000066263 | ENSRNOP00000042136 | Erbb2-interacting protein. | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.758 |
Erbin | Adgrl3 | ENSRNOP00000066263 | ENSRNOP00000045365 | Erbb2-interacting protein. | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | 0.710 |
Erbin | Arvcf | ENSRNOP00000066263 | ENSRNOP00000047113 | Erbb2-interacting protein. | ARVCF, delta catenin family member. | 0.737 |
Erbin | Dsg1 | ENSRNOP00000066263 | ENSRNOP00000058060 | Erbb2-interacting protein. | Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.726 |
Erbin | Erbb2 | ENSRNOP00000066263 | ENSRNOP00000040591 | Erbb2-interacting protein. | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | 0.994 |
Erbin | LOC102552659 | ENSRNOP00000066263 | ENSRNOP00000064298 | Erbb2-interacting protein. | Receptor tyrosine-protein kinase erbB-2-like. | 0.733 |
Erbin | Nod2 | ENSRNOP00000066263 | ENSRNOP00000073236 | Erbb2-interacting protein. | Caspase recruitment domain family, member 15 (Predicted). | 0.981 |
Erbin | Pkp4 | ENSRNOP00000066263 | ENSRNOP00000056013 | Erbb2-interacting protein. | Plakophilin 4. | 0.830 |
Erbin | Smad2 | ENSRNOP00000066263 | ENSRNOP00000075341 | Erbb2-interacting protein. | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] | 0.671 |