node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dhx58 | Eif2ak2 | ENSRNOP00000024718 | ENSRNOP00000071646 | DEXH-box helicase 58. | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | 0.780 |
Dhx58 | Ifi44 | ENSRNOP00000024718 | ENSRNOP00000071211 | DEXH-box helicase 58. | Interferon-induced protein 44, isoform CRA_a. | 0.723 |
Dhx58 | Ifit1 | ENSRNOP00000024718 | ENSRNOP00000025770 | DEXH-box helicase 58. | Interferon-induced protein with tetratricopeptide repeats 1. | 0.738 |
Dhx58 | Irf7 | ENSRNOP00000024718 | ENSRNOP00000023504 | DEXH-box helicase 58. | Interferon regulatory factor 7. | 0.889 |
Dhx58 | Isg15 | ENSRNOP00000024718 | ENSRNOP00000035405 | DEXH-box helicase 58. | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | 0.829 |
Dhx58 | Mx2 | ENSRNOP00000024718 | ENSRNOP00000002695 | DEXH-box helicase 58. | Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions. | 0.701 |
Dhx58 | Nod2 | ENSRNOP00000024718 | ENSRNOP00000073236 | DEXH-box helicase 58. | Caspase recruitment domain family, member 15 (Predicted). | 0.569 |
Dhx58 | Oas2 | ENSRNOP00000024718 | ENSRNOP00000073899 | DEXH-box helicase 58. | 2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antivir [...] | 0.790 |
Dhx58 | Rnasel | ENSRNOP00000024718 | ENSRNOP00000032975 | DEXH-box helicase 58. | Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent). | 0.603 |
Dhx58 | Rsad2 | ENSRNOP00000024718 | ENSRNOP00000010092 | DEXH-box helicase 58. | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.838 |
Eif2ak2 | Dhx58 | ENSRNOP00000071646 | ENSRNOP00000024718 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | DEXH-box helicase 58. | 0.780 |
Eif2ak2 | Ifi44 | ENSRNOP00000071646 | ENSRNOP00000071211 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon-induced protein 44, isoform CRA_a. | 0.884 |
Eif2ak2 | Ifit1 | ENSRNOP00000071646 | ENSRNOP00000025770 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon-induced protein with tetratricopeptide repeats 1. | 0.981 |
Eif2ak2 | Irf7 | ENSRNOP00000071646 | ENSRNOP00000023504 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon regulatory factor 7. | 0.851 |
Eif2ak2 | Isg15 | ENSRNOP00000071646 | ENSRNOP00000035405 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted). | 0.987 |
Eif2ak2 | Mx2 | ENSRNOP00000071646 | ENSRNOP00000002695 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions. | 0.822 |
Eif2ak2 | Nod2 | ENSRNOP00000071646 | ENSRNOP00000073236 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Caspase recruitment domain family, member 15 (Predicted). | 0.575 |
Eif2ak2 | Oas2 | ENSRNOP00000071646 | ENSRNOP00000073899 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | 2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antivir [...] | 0.846 |
Eif2ak2 | Rnasel | ENSRNOP00000071646 | ENSRNOP00000032975 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent). | 0.903 |
Eif2ak2 | Rsad2 | ENSRNOP00000071646 | ENSRNOP00000010092 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] | 0.927 |