node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adipoq | Ccrl2 | ENSRNOP00000002492 | ENSRNOP00000044084 | Adiponectin, C1Q and collagen domain-containing. | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | 0.524 |
Adipoq | Gpr1 | ENSRNOP00000002492 | ENSRNOP00000067327 | Adiponectin, C1Q and collagen domain-containing. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.601 |
Adipoq | Nampt | ENSRNOP00000002492 | ENSRNOP00000013043 | Adiponectin, C1Q and collagen domain-containing. | Nicotinamide phosphoribosyltransferase; Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock fun [...] | 0.817 |
Adipoq | Rarres2 | ENSRNOP00000002492 | ENSRNOP00000038525 | Adiponectin, C1Q and collagen domain-containing. | Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a. | 0.647 |
Adipoq | Retn | ENSRNOP00000002492 | ENSRNOP00000073327 | Adiponectin, C1Q and collagen domain-containing. | Resistin. | 0.978 |
Adipoq | Retnlg | ENSRNOP00000002492 | ENSRNOP00000002673 | Adiponectin, C1Q and collagen domain-containing. | Resistin-like gamma; Probable hormone (Probable). Promotes chemotaxis in myeloid cells (By similarity); Belongs to the resistin/FIZZ family. | 0.955 |
Arrb1 | Gnao1 | ENSRNOP00000046069 | ENSRNOP00000026373 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity); Belongs to the G-alpha family. G(i/o/t/z) subfamily. | 0.468 |
Arrb1 | Gpr1 | ENSRNOP00000046069 | ENSRNOP00000067327 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.537 |
Ccrl2 | Adipoq | ENSRNOP00000044084 | ENSRNOP00000002492 | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | Adiponectin, C1Q and collagen domain-containing. | 0.524 |
Ccrl2 | Gpr1 | ENSRNOP00000044084 | ENSRNOP00000067327 | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.875 |
Ccrl2 | Nampt | ENSRNOP00000044084 | ENSRNOP00000013043 | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | Nicotinamide phosphoribosyltransferase; Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock fun [...] | 0.699 |
Ccrl2 | Rarres2 | ENSRNOP00000044084 | ENSRNOP00000038525 | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | Retinoic acid receptor responder (Tazarotene induced) 2, isoform CRA_a. | 0.885 |
Ccrl2 | Retnlg | ENSRNOP00000044084 | ENSRNOP00000002673 | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | Resistin-like gamma; Probable hormone (Probable). Promotes chemotaxis in myeloid cells (By similarity); Belongs to the resistin/FIZZ family. | 0.418 |
Gnao1 | Arrb1 | ENSRNOP00000026373 | ENSRNOP00000046069 | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity); Belongs to the G-alpha family. G(i/o/t/z) subfamily. | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | 0.468 |
Gnao1 | Gpr1 | ENSRNOP00000026373 | ENSRNOP00000067327 | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity); Belongs to the G-alpha family. G(i/o/t/z) subfamily. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.567 |
Gpha2 | Gpr1 | ENSRNOP00000028536 | ENSRNOP00000067327 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.955 |
Gpr1 | Adipoq | ENSRNOP00000067327 | ENSRNOP00000002492 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | Adiponectin, C1Q and collagen domain-containing. | 0.601 |
Gpr1 | Arrb1 | ENSRNOP00000067327 | ENSRNOP00000046069 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | 0.537 |
Gpr1 | Ccrl2 | ENSRNOP00000067327 | ENSRNOP00000044084 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | Chemokine (C-C motif) receptor-like 2 (Predicted); Belongs to the G-protein coupled receptor 1 family. | 0.875 |
Gpr1 | Gnao1 | ENSRNOP00000067327 | ENSRNOP00000026373 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity); Belongs to the G-alpha family. G(i/o/t/z) subfamily. | 0.567 |