node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bub1 | Bub1b | ENSRNOP00000042114 | ENSRNOP00000010406 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | BUB1 mitotic checkpoint serine/threonine kinase B. | 0.996 |
Bub1 | Cdc20 | ENSRNOP00000042114 | ENSRNOP00000037772 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] | 0.999 |
Bub1 | Dsn1 | ENSRNOP00000042114 | ENSRNOP00000008255 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | DSN1, MIND kinetochore complex component, homolog (S. cerevisiae). | 0.862 |
Bub1 | Ndc80 | ENSRNOP00000042114 | ENSRNOP00000072111 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | NDC80 kinetochore complex component. | 0.987 |
Bub1 | Nsl1 | ENSRNOP00000042114 | ENSRNOP00000059540 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Similar to DC8/DC31 protein (Predicted), isoform CRA_b. | 0.640 |
Bub1 | Nuf2 | ENSRNOP00000042114 | ENSRNOP00000003650 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Kinetochore protein Nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Belongs to the NUF2 family. | 0.977 |
Bub1 | Spc24 | ENSRNOP00000042114 | ENSRNOP00000045819 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | SPC24 component of NDC80 kinetochore complex. | 0.782 |
Bub1 | Zw10 | ENSRNOP00000042114 | ENSRNOP00000071533 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assemb [...] | 0.788 |
Bub1 | Zwilch | ENSRNOP00000042114 | ENSRNOP00000012404 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | Zwilch kinetochore protein. | 0.888 |
Bub1 | Zwint | ENSRNOP00000042114 | ENSRNOP00000067414 | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | ZW10 interactor; Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity). | 0.904 |
Bub1b | Bub1 | ENSRNOP00000010406 | ENSRNOP00000042114 | BUB1 mitotic checkpoint serine/threonine kinase B. | Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted). | 0.996 |
Bub1b | Cdc20 | ENSRNOP00000010406 | ENSRNOP00000037772 | BUB1 mitotic checkpoint serine/threonine kinase B. | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] | 0.999 |
Bub1b | Dsn1 | ENSRNOP00000010406 | ENSRNOP00000008255 | BUB1 mitotic checkpoint serine/threonine kinase B. | DSN1, MIND kinetochore complex component, homolog (S. cerevisiae). | 0.761 |
Bub1b | Ndc80 | ENSRNOP00000010406 | ENSRNOP00000072111 | BUB1 mitotic checkpoint serine/threonine kinase B. | NDC80 kinetochore complex component. | 0.991 |
Bub1b | Nsl1 | ENSRNOP00000010406 | ENSRNOP00000059540 | BUB1 mitotic checkpoint serine/threonine kinase B. | Similar to DC8/DC31 protein (Predicted), isoform CRA_b. | 0.530 |
Bub1b | Nuf2 | ENSRNOP00000010406 | ENSRNOP00000003650 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinetochore protein Nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Belongs to the NUF2 family. | 0.952 |
Bub1b | Spc24 | ENSRNOP00000010406 | ENSRNOP00000045819 | BUB1 mitotic checkpoint serine/threonine kinase B. | SPC24 component of NDC80 kinetochore complex. | 0.654 |
Bub1b | Zw10 | ENSRNOP00000010406 | ENSRNOP00000071533 | BUB1 mitotic checkpoint serine/threonine kinase B. | Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assemb [...] | 0.661 |
Bub1b | Zwilch | ENSRNOP00000010406 | ENSRNOP00000012404 | BUB1 mitotic checkpoint serine/threonine kinase B. | Zwilch kinetochore protein. | 0.757 |
Bub1b | Zwint | ENSRNOP00000010406 | ENSRNOP00000067414 | BUB1 mitotic checkpoint serine/threonine kinase B. | ZW10 interactor; Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity). | 0.925 |