node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acan | Itgb1 | ENSRNOP00000042691 | ENSRNOP00000014785 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.553 |
Acan | Sdc1 | ENSRNOP00000042691 | ENSRNOP00000072283 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. | 0.409 |
Acan | Sdc4 | ENSRNOP00000042691 | ENSRNOP00000019386 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. | 0.507 |
Acan | Tnc | ENSRNOP00000042691 | ENSRNOP00000071884 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Tenascin C. | 0.666 |
Acan | Tnn | ENSRNOP00000042691 | ENSRNOP00000003452 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Tenascin N. | 0.563 |
Acan | Tnr | ENSRNOP00000042691 | ENSRNOP00000068101 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repul [...] | 0.977 |
Acan | Vtn | ENSRNOP00000042691 | ENSRNOP00000075508 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Vitronectin. | 0.531 |
Itga8 | Itga9 | ENSRNOP00000022713 | ENSRNOP00000015113 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | 0.736 |
Itga8 | Itgb1 | ENSRNOP00000022713 | ENSRNOP00000014785 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.987 |
Itga8 | Itgb6 | ENSRNOP00000022713 | ENSRNOP00000074271 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). | 0.941 |
Itga8 | Tnc | ENSRNOP00000022713 | ENSRNOP00000071884 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Tenascin C. | 0.916 |
Itga8 | Tnn | ENSRNOP00000022713 | ENSRNOP00000003452 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Tenascin N. | 0.913 |
Itga8 | Tnr | ENSRNOP00000022713 | ENSRNOP00000068101 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repul [...] | 0.912 |
Itga8 | Vtn | ENSRNOP00000022713 | ENSRNOP00000075508 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Vitronectin. | 0.988 |
Itga9 | Itga8 | ENSRNOP00000015113 | ENSRNOP00000022713 | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | 0.736 |
Itga9 | Itgb1 | ENSRNOP00000015113 | ENSRNOP00000014785 | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.992 |
Itga9 | Itgb6 | ENSRNOP00000015113 | ENSRNOP00000074271 | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). | 0.902 |
Itga9 | Tnc | ENSRNOP00000015113 | ENSRNOP00000071884 | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | Tenascin C. | 0.947 |
Itga9 | Tnn | ENSRNOP00000015113 | ENSRNOP00000003452 | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | Tenascin N. | 0.912 |
Itga9 | Tnr | ENSRNOP00000015113 | ENSRNOP00000068101 | Integrin subunit alpha 9; Belongs to the integrin alpha chain family. | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repul [...] | 0.918 |