STRINGSTRING
TOP3B protein (Cavia porcellus) - STRING interaction network
"TOP3B" - DNA topoisomerase in Cavia porcellus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (862 aa)    
Predicted Functional Partners:
RMI1
RecQ mediated genome instability 1 (617 aa)
     
  0.991
BLM
Bloom syndrome, RecQ helicase-like (1410 aa)
     
  0.984
RMI2
RecQ mediated genome instability 2 (149 aa)
     
  0.971
TDRD3
Tudor domain containing 3 (611 aa)
     
  0.968
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (1002 aa)
     
 
0.950
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (616 aa)
     
  0.909
RPA4
Replication protein A4, 30kDa (253 aa)
     
  0.882
RPA2
Replication protein A2, 32kDa (270 aa)
     
  0.882
MUS81
MUS81 structure-specific endonuclease subunit (551 aa)
   
  0.830
WRN
Werner syndrome, RecQ helicase-like (1433 aa)
     
  0.795
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, Cavia cobya, Cavia porcellus, domestic guinea pig, guinea pig
Server load: low (12%) [HD]