node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSCPOP00000022441 | GUCA2A | ENSCPOP00000022441 | ENSCPOP00000015206 | ANF_receptor domain-containing protein. | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | 0.768 |
ENSCPOP00000022441 | GUCA2B | ENSCPOP00000022441 | ENSCPOP00000006119 | ANF_receptor domain-containing protein. | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. | 0.768 |
ENSCPOP00000022441 | GUCY2C | ENSCPOP00000022441 | ENSCPOP00000007653 | ANF_receptor domain-containing protein. | Heat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.660 |
GUCA2A | ENSCPOP00000022441 | ENSCPOP00000015206 | ENSCPOP00000022441 | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | ANF_receptor domain-containing protein. | 0.768 |
GUCA2A | GUCA2B | ENSCPOP00000015206 | ENSCPOP00000006119 | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. | 0.932 |
GUCA2A | GUCY2C | ENSCPOP00000015206 | ENSCPOP00000007653 | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | Heat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.972 |
GUCA2A | GUCY2D | ENSCPOP00000015206 | ENSCPOP00000001343 | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | Guanylate cyclase. | 0.686 |
GUCA2A | GUCY2F | ENSCPOP00000015206 | ENSCPOP00000005720 | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | Guanylate cyclase. | 0.686 |
GUCA2A | LOC100735737 | ENSCPOP00000015206 | ENSCPOP00000000633 | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.499 |
GUCA2A | NPR1 | ENSCPOP00000015206 | ENSCPOP00000017436 | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | Guanylate cyclase. | 0.681 |
GUCA2A | NPR2 | ENSCPOP00000015206 | ENSCPOP00000000365 | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | Guanylate cyclase. | 0.689 |
GUCA2A | PDZD3 | ENSCPOP00000015206 | ENSCPOP00000014360 | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | PDZ domain containing 3. | 0.609 |
GUCA2B | ENSCPOP00000022441 | ENSCPOP00000006119 | ENSCPOP00000022441 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. | ANF_receptor domain-containing protein. | 0.768 |
GUCA2B | GUCA2A | ENSCPOP00000006119 | ENSCPOP00000015206 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. | 0.932 |
GUCA2B | GUCY2C | ENSCPOP00000006119 | ENSCPOP00000007653 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. | Heat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.972 |
GUCA2B | GUCY2D | ENSCPOP00000006119 | ENSCPOP00000001343 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. | Guanylate cyclase. | 0.594 |
GUCA2B | GUCY2F | ENSCPOP00000006119 | ENSCPOP00000005720 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. | Guanylate cyclase. | 0.606 |
GUCA2B | H0UUP4_CAVPO | ENSCPOP00000006119 | ENSCPOP00000000692 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. | Folate_rec domain-containing protein. | 0.561 |
GUCA2B | LOC100735737 | ENSCPOP00000006119 | ENSCPOP00000000633 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. | Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.524 |
GUCA2B | NPR1 | ENSCPOP00000006119 | ENSCPOP00000017436 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. | Guanylate cyclase. | 0.580 |