node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACVR1B | SMAD6 | ENSCPOP00000001026 | ENSCPOP00000001388 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Mothers against decapentaplegic homolog. | 0.908 |
ACVR1B | TAPT1 | ENSCPOP00000001026 | ENSCPOP00000007070 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Transmembrane anterior posterior transformation 1. | 0.594 |
BMPR1A | LEP | ENSCPOP00000018932 | ENSCPOP00000029200 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.614 |
BMPR1A | MEOX2 | ENSCPOP00000018932 | ENSCPOP00000016379 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mesenchyme homeobox 2. | 0.697 |
BMPR1A | PDX1 | ENSCPOP00000018932 | ENSCPOP00000019973 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Pancreatic and duodenal homeobox 1. | 0.640 |
BMPR1A | SMAD6 | ENSCPOP00000018932 | ENSCPOP00000001388 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog. | 0.927 |
BMPR1A | TAPT1 | ENSCPOP00000018932 | ENSCPOP00000007070 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Transmembrane anterior posterior transformation 1. | 0.736 |
CSTF1 | TAPT1 | ENSCPOP00000022139 | ENSCPOP00000007070 | Cleavage stimulation factor subunit 1. | Transmembrane anterior posterior transformation 1. | 0.787 |
INSR | LEP | ENSCPOP00000011692 | ENSCPOP00000029200 | Tyrosine-protein kinase receptor. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.713 |
INSR | MEOX2 | ENSCPOP00000011692 | ENSCPOP00000016379 | Tyrosine-protein kinase receptor. | Mesenchyme homeobox 2. | 0.677 |
INSR | PDX1 | ENSCPOP00000011692 | ENSCPOP00000019973 | Tyrosine-protein kinase receptor. | Pancreatic and duodenal homeobox 1. | 0.532 |
INSR | SMAD6 | ENSCPOP00000011692 | ENSCPOP00000001388 | Tyrosine-protein kinase receptor. | Mothers against decapentaplegic homolog. | 0.725 |
INSR | TAPT1 | ENSCPOP00000011692 | ENSCPOP00000007070 | Tyrosine-protein kinase receptor. | Transmembrane anterior posterior transformation 1. | 0.696 |
LEP | BMPR1A | ENSCPOP00000029200 | ENSCPOP00000018932 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.614 |
LEP | INSR | ENSCPOP00000029200 | ENSCPOP00000011692 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Tyrosine-protein kinase receptor. | 0.713 |
LEP | MEOX2 | ENSCPOP00000029200 | ENSCPOP00000016379 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Mesenchyme homeobox 2. | 0.611 |
LEP | PDX1 | ENSCPOP00000029200 | ENSCPOP00000019973 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Pancreatic and duodenal homeobox 1. | 0.611 |
LEP | SMAD6 | ENSCPOP00000029200 | ENSCPOP00000001388 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Mothers against decapentaplegic homolog. | 0.611 |
LEP | TAPT1 | ENSCPOP00000029200 | ENSCPOP00000007070 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Transmembrane anterior posterior transformation 1. | 0.648 |
MEOX2 | BMPR1A | ENSCPOP00000016379 | ENSCPOP00000018932 | Mesenchyme homeobox 2. | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.697 |