STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRNParagranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule str [...] (605 aa)    
Predicted Functional Partners:
CS
Citrate synthase; Belongs to the citrate synthase family.
   
   0.885
C15orf40
Chromosome 15 open reading frame 40.
    
   0.881
SLC25A1
Solute carrier family 25 member 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.
    
   0.881
POLE2
DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.
    
   0.881
DRG1
Developmentally regulated GTP binding protein 1.
    
   0.881
CXorf56
Chromosome X open reading frame 56.
    
   0.881
CTSZ
Cathepsin Z; Belongs to the peptidase C1 family.
   
 0.831
CTSB
Cathepsin B; Belongs to the peptidase C1 family.
   
 0.796
DRG2
Developmentally regulated GTP binding protein 2.
    
   0.774
Csnk2a1
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
   0.774
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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