STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
P2RX2P2X purinoceptor 2; Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity); Belongs to the P2X receptor family. (411 aa)    
Predicted Functional Partners:
P2RX6
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
  
 
0.923
P2RX3
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
  
  
0.911
P2rx4
Uncharacterized protein.
  
 
0.900
P2RX1
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
  
 
0.890
P2rx5
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
  
 
0.871
P2rx7
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.
  
 
0.848
GRIN2C
Glutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
     
 0.806
GRIN2D
Glutamate ionotropic receptor NMDA type subunit 2D.
     
 0.794
GRIN1
Glutamate ionotropic receptor NMDA type subunit 1.
     
 0.793
GRIN2A
Glutamate ionotropic receptor NMDA type subunit 2A.
     
 0.788
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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