SNCA protein (Cavia porcellus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

SNCA

Alpha-synuclein; Belongs to the synuclein family. (140 aa)

Predicted Functional Partners:

TH

0.981

PRKN

0.979

SNCAIP

0.966

SLC18A2

0.945

HSPA4

0.933

SLC6A3

0.928

SLC18A1

0.925

APP

0.925

KLC2

0.924

KLC1

0.924

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	HSPA4	ENSCPOP00000020780	ENSCPOP00000003686	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Heat shock protein family A (Hsp70) member 4.	0.518
APP	KLC1	ENSCPOP00000020780	ENSCPOP00000017390	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Kinesin light chain 1.	0.663
APP	KLC2	ENSCPOP00000020780	ENSCPOP00000013391	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Kinesin light chain 2.	0.719
APP	PRKN	ENSCPOP00000020780	ENSCPOP00000005534	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.515
APP	SNCA	ENSCPOP00000020780	ENSCPOP00000026441	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Alpha-synuclein; Belongs to the synuclein family.	0.925
HSPA4	APP	ENSCPOP00000003686	ENSCPOP00000020780	Heat shock protein family A (Hsp70) member 4.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.518
HSPA4	KLC1	ENSCPOP00000003686	ENSCPOP00000017390	Heat shock protein family A (Hsp70) member 4.	Kinesin light chain 1.	0.405
HSPA4	KLC2	ENSCPOP00000003686	ENSCPOP00000013391	Heat shock protein family A (Hsp70) member 4.	Kinesin light chain 2.	0.405
HSPA4	PRKN	ENSCPOP00000003686	ENSCPOP00000005534	Heat shock protein family A (Hsp70) member 4.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.854
HSPA4	SNCA	ENSCPOP00000003686	ENSCPOP00000026441	Heat shock protein family A (Hsp70) member 4.	Alpha-synuclein; Belongs to the synuclein family.	0.933
KLC1	APP	ENSCPOP00000017390	ENSCPOP00000020780	Kinesin light chain 1.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.663
KLC1	HSPA4	ENSCPOP00000017390	ENSCPOP00000003686	Kinesin light chain 1.	Heat shock protein family A (Hsp70) member 4.	0.405
KLC1	KLC2	ENSCPOP00000017390	ENSCPOP00000013391	Kinesin light chain 1.	Kinesin light chain 2.	0.985
KLC1	SNCA	ENSCPOP00000017390	ENSCPOP00000026441	Kinesin light chain 1.	Alpha-synuclein; Belongs to the synuclein family.	0.924
KLC2	APP	ENSCPOP00000013391	ENSCPOP00000020780	Kinesin light chain 2.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.719
KLC2	HSPA4	ENSCPOP00000013391	ENSCPOP00000003686	Kinesin light chain 2.	Heat shock protein family A (Hsp70) member 4.	0.405
KLC2	KLC1	ENSCPOP00000013391	ENSCPOP00000017390	Kinesin light chain 2.	Kinesin light chain 1.	0.985
KLC2	SNCA	ENSCPOP00000013391	ENSCPOP00000026441	Kinesin light chain 2.	Alpha-synuclein; Belongs to the synuclein family.	0.924
KLC2	SNCAIP	ENSCPOP00000013391	ENSCPOP00000025258	Kinesin light chain 2.	Synuclein alpha interacting protein.	0.409
PRKN	APP	ENSCPOP00000005534	ENSCPOP00000020780	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.515